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Genentech Inc., South San Francisco, Calif. Product: MEHD7945A Business: Cancer Indication: Treat cancer In mouse xenograft models of non-small cell lung cancer (NSCLC), MEHD7945A, a humanized IgG1 mAb targeting both …
Published on 10/31/2011
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Idera Pharmaceuticals Inc. (NASDAQ:IDRA), Cambridge, Mass. Product: GSO targeting APOB Business: Cardiovascular Indication: Treat cardiovascular disease In mice, subcutaneous administration of Idera's gene-silencing …
Published on 10/31/2011
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Idera Pharmaceuticals Inc. (NASDAQ:IDRA), Cambridge, Mass. Product: GSO targeting PCSK9 Business: Cardiovascular Indication: Treat cardiovascular disease In mice, subcutaneous administration of Idera's gene-silencing …
Published on 10/31/2011
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Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: Anti-CCR2-siRNA Business: Cancer, Cardiovascular Indication: Treat myocardial infarction (MI), atherosclerosis and lymphoma In a mouse model of MI, …
Published on 10/17/2011
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AstraZeneca plc (LSE:AZN; NYSE:AZN), London, U.K. Product: S. aureus anti-alpha toxin mAbs Business: Infectious Indication: Treat methicillin-resistant Staphylococcus aureus (MRSA) infection In mice with soft tissue …
Published on 10/17/2011
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Cellceutix Corp. (OTCQB:CTIX), Beverly, Mass. Product: Kevetrin Business: Cancer Indication: Treat prostate cancer In a mouse xenograft model of prostate cancer, 200 mg/kg intraperitoneal Kevetrin every other day for 3 …
Published on 10/17/2011
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Cellceutix Corp. (OTCQB:CTIX), Beverly, Mass. Product: KM-133 Business: Autoimmune Indication: Treat psoriasis In mouse xenograft models of psoriasis, KM-133 led to a faster reduction in lesion appearance and a …
Published on 10/17/2011
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Cleveland BioLabs Inc. (NASDAQ:CBLI), Buffalo, N.Y. Product: Protectan (CBLB502) Business: Renal Indication: Treat acute renal ischemic failure In mice, CBLB502 given 30 minutes before bilateral renal pedicle occlusion …
Published on 10/17/2011
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Eurocine Vaccines AB, Solna, Sweden Product: Endocine Business: Infectious Indication: Prevent influenza virus infection In ferrets, 3 doses of intranasal Endocine protected all animals against influenza infection in …
Published on 10/17/2011
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Laurantis Pharma Oy, Turku, Finland Product: Lymfactin (AdVEGF-C) Business: Inflammation Indication: Treat secondary lymphedema In a porcine model of lymphedema, Lymfactin given with autologous lymph node transfer …
Published on 10/17/2011
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MediGene AG (Xetra:MDG), Martinsried, Germany Product: AAVLP (HPV16/31L2) Business: Infectious Indication: Prevent HPV infection In mice and rabbits, adeno-associated virus-like particles (AAVLPs) presenting HPV minor …
Published on 10/17/2011
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ProtoKinetix Inc. (OTCBB:PKTX), Vancouver, B.C. Product: AAGP Business: Inflammation Indication: Treat eye inflammation In rats, 0.2% topical AAGP penetrated the protective barriers of the eye and was detected within …
Published on 10/17/2011
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Pulmatrix Inc., Lexington, Mass. Product: PUR118 Business: Pulmonary Indication: Treat respiratory diseases In a mouse model of acute tobacco smoke-induced airway inflammation, once-daily PUR118 given 1 hour before …
Published on 10/17/2011
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SomaGenics Inc., Santa Cruz, Calif. Product: SG220; SG273 Business: Infectious Indication: Treat HCV infection In HCV-infected mice, a single dose of 2.5 mg/kg IV SG273 or SG220 led to significant mean maximal …
Published on 10/17/2011
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Beech Tree Labs Inc., Providence, R.I. Product: BTL-slo Business: Infectious Indication: Treat tuberculosis (TB) In foals challenged with Rhodococcus equi, BTL-slo as an adjunct to clarithromycin and rifampin …
Published on 10/10/2011
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Circadian Technologies Ltd. (ASX:CIR; OTCQX:CKDXY), Toorak, Australia Product: VGX-100 Business: Ophthalmic Indication: Treat dry eye disease In a mouse model of dry eye disease, intraperitoneal injections of 400 g VGX-…
Published on 10/10/2011
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Cornerstone Pharmaceuticals Inc., Cranbury, N.J. Product: EmPAC Business: Cancer Indication: Treat cancer In mouse xenograft models of melanoma and non-small cell lung cancer (NSCLC), EmPAC produced greater tumor growth…
Published on 10/10/2011
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CZ BioMed Corp., Tampa, Fla. Product: Panrvlysin Business: Cancer Indication: Treat pancreatic cancer In mice, panrvlysin was well tolerated and induced tumor growth regression. Details were not disclosed. CZ BioMed …
Published on 10/10/2011
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Genfit S.A. (Euronext:ALGFT), Lille, France Product: GFT505 Business: Hepatic Indication: Treat non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) In a mouse model of NAFLD/NASH, oral GFT505 …
Published on 10/10/2011
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GlycoVaxyn AG, Schlieren, Switzerland Product: Staphylococcus aureus vaccine Business: Infectious Indication: Vaccinate against Staphylococcus aureus infection In mice, GlycoVaxyn's S. aureus vaccine significantly …
Published on 10/10/2011
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iBio Inc. (NYSE-A:IBIO), Newark, Del. Product: Biosimilar rituximab Business: Autoimmune, Cancer Indication: Treat autoimmune diseases and cancer iBio said it used its iBioLaunch technology to produce a functional …
Published on 10/10/2011
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MGB Biopharma Ltd., Glasgow, U.K. Product: MGB-BP-3 Business: Infectious Indication: Treat Clostridium difficile-associated diarrhea (CDAD) In a hamster model of CDAD, twice-daily 10 mg MGB-BP-3 given as a freebase …
Published on 10/10/2011
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NicOx S.A. (Euronext:COX), Sophia-Antipolis, France Product: NCX 6560 Business: Musculoskeletal Indication: Prevent statin-induced myopathy In mice, 40 mg/kg/day Lipitor atorvastatin impaired locomotor and muscle …
Published on 10/10/2011
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Prolor Biotech Inc. (NYSE-A:PBTH; Tel Aviv:PBTH), Nes Ziona, Israel Product: Factor VIIa-CTP Business: Hematology Indication: Treat hemophilia In a mouse model of hemophilia, Prolor's Factor VIIa-CTP showed a …
Published on 10/10/2011
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Summit Corp. plc (LSE:SUMM), Abingdon, U.K. Product: SMT 19969 Business: Infectious Indication: Treat Clostridium difficile-associated diarrhea (CDAD) In hamsters infected with the BI/NAP1 strain of C. difficile, once-…
Published on 10/10/2011