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Rhizen Pharmaceuticals S.A., La Chaux-de-Fonds, Switzerland TG Therapeutics Inc. (OTCBB:TGTX), New York, N.Y. Product: TGR-1202 (formerly RP5264) Business: Cancer Indication: Treat B cell lymphoma In antigen recognition…
Published on 1/21/2013
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Rhizen Pharmaceuticals S.A., La Chaux-de-Fonds, Switzerland TG Therapeutics Inc. (OTCBB:TGTX), New York, N.Y. Product: TGR-1202 (formerly RP5264) Business: Cancer Indication: Treat chronic lymphocytic leukemia (CLL) In …
Published on 1/21/2013
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Epizyme Inc., Cambridge, Mass. Product: E7438 Business: Cancer Indication: Treat lymphoma In mice subcutaneously implanted with human lymphomas that have enhancer of zeste homolog 2 (EZH2) mutations, oral E7438 led to …
Published on 1/14/2013
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Genervon Biopharmaceuticals LLC, Pasadena, Calif. Product: GM604 Business: Neurology Indication: Treat amyotrophic lateral sclerosis (ALS) In a mouse model of ALS with mutant superoxide dismutase 1 (SOD1), GM604 …
Published on 1/14/2013
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GenVec Inc. (NASDAQ:GNVC), Gaithersburg, Md. Product: HSV-2 vaccine Business: Infectious Indication: Treat and prevent herpes simplex virus type 2 (HSV-2) infection In a mouse model of HSV-2 infection, a single …
Published on 1/14/2013
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Portola Pharmaceuticals Inc., South San Francisco, Calif. Product: PRT060318 Business: Cancer Indication: Treat acute lymphoblastic leukemia (ALL) In vitro, PRT060318 inhibited ALL cell proliferation. PRT060318 is a …
Published on 1/14/2013
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Portola Pharmaceuticals Inc., South San Francisco, Calif. Product: PRT062070 Business: Autoimmune Indication: Treat rheumatoid arthritis (RA) In a mouse model of arthritis, PRT062070 suppressed inflammation. In a rat …
Published on 1/14/2013
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Portola Pharmaceuticals Inc., South San Francisco, Calif. Product: PRT062070 Business: Cancer Indication: Treat non-Hodgkin's lymphoma (NHL) In a mouse xenograft model of B cell NHL, PRT062070 diminished progression of …
Published on 1/14/2013
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Sirnaomics Inc., Gaithersburg, Md. Product: STP909 Business: Infectious Indication: Treat HPV infection In a rabbit skin papilloma model, topical STP909 stopped growth of papillomavirus. Details were not disclosed. Data…
Published on 1/14/2013
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GlycoMimetics Inc., Gaithersburg, Md. Product: GMI-1271 Business: Cancer Indication: Treat acute myelogenous leukemia (AML) In a mouse xenograft model of AML, GMI-1271 plus daunorubicin and cytarabine led to greater …
Published on 12/24/2012
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GlycoMimetics Inc., Gaithersburg, Md. Product: GMI-1271 Business: Cardiovascular Indication: Treat non-occlusive thrombosis In a mouse model of non-occlusive thrombosis, 10 mg/kg GMI-1271 significantly reduced venous …
Published on 12/24/2012
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Obetherapy Biotechnology, Evry, France Product: OBE-2008 Business: Endocrine/Metabolic Indication: Treat obesity In a mouse model of diet-induced obesity, once-daily OBE-2008 for up to 9 weeks significantly reduced …
Published on 12/24/2012
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Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: ALN-AAT Business: Hepatic Indication: Treat liver disease caused by alpha 1-antitrypsin (AAT; A1AT; SERPINA1) deficiency In a mouse model of AAT …
Published on 12/17/2012
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Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: ALN-AAT Business: Hepatic Indication: Treat liver disease caused by alpha 1-antitrypsin (AAT; A1AT; SERPINA1) deficiency In a mouse model of AAT …
Published on 12/17/2012
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CureVac GmbH, Tuebingen, Germany Product: RNActive influenza A vaccine Business: Infectious Indication: Prevent influenza A infection In mice infected with influenza A, RNActive vaccines were immunogenic and provided …
Published on 12/17/2012
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CureVac GmbH, Tuebingen, Germany Product: RNActive influenza A vaccine Business: Infectious Indication: Prevent influenza A infection In mice infected with influenza A, RNActive vaccines were immunogenic and provided …
Published on 12/17/2012
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Inovio Pharmaceuticals Inc. (NYSE-M:INO), Blue Bell, Pa. Product: SynCon DNA CMV vaccine Business: Infectious Indication: Prevent cytomegalovirus (CMV) infection In mice, Inovio's SynCon DNA CMV vaccine delivered with …
Published on 12/17/2012
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Inovio Pharmaceuticals Inc. (NYSE-M:INO), Blue Bell, Pa. Product: SynCon DNA HBV vaccine Business: Infectious Indication: Prevent HBV infection In mice, Inovio's SynCon DNA HBV vaccine delivered with the company's …
Published on 12/17/2012
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Inovio Pharmaceuticals Inc. (NYSE-M:INO), Blue Bell, Pa. Product: SynCon DNA CMV vaccine Business: Infectious Indication: Prevent cytomegalovirus (CMV) infection In mice, Inovio's SynCon DNA CMV vaccine delivered with …
Published on 12/17/2012
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Inovio Pharmaceuticals Inc. (NYSE-M:INO), Blue Bell, Pa. Product: SynCon DNA HBV vaccine Business: Infectious Indication: Prevent HBV infection In mice, Inovio's SynCon DNA HBV vaccine delivered with the company's …
Published on 12/17/2012
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Karyopharm Therapeutics Inc., Natick, Mass. Product: SINE CRM1 antagonist Business: Autoimmune Indication: Treat systemic lupus erythematosus (SLE) In an animal model of SLE, oral selective inhibitor of nuclear export (…
Published on 12/17/2012
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Karyopharm Therapeutics Inc., Natick, Mass. Product: SINE CRM1 antagonist Business: Autoimmune Indication: Treat systemic lupus erythematosus (SLE) In an animal model of SLE, oral selective inhibitor of nuclear export (…
Published on 12/17/2012
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Merrimack Pharmaceuticals Inc. (NASDAQ:MACK), Cambridge, Mass. Product: 64Cu-Liposomal PET Agent (MM-DX-929) Business: Diagnostic Indication: Predict response to the liposomal chemotherapeutic MM-302 in patients with …
Published on 12/17/2012
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Merrimack Pharmaceuticals Inc. (NASDAQ:MACK), Cambridge, Mass. Product: 64Cu-Liposomal PET Agent (MM-DX-929) Business: Diagnostic Indication: Predict response to the liposomal chemotherapeutic MM-302 in patients with …
Published on 12/17/2012
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Nimbus Discovery LLC, Cambridge, Mass. Product: ND-2110 Business: Autoimmune Indication: Treat rheumatic diseases In a mouse model of collagen-induced arthritis, twice-daily 30 mg/kg intraperitoneal ND-2110 …
Published on 12/17/2012