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Chronological Index of : Preclinical Results

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  • Jenrin preclinical data

    Jenrin Discovery Inc., West Chester, Pa. Product: JD-5037 Business: Endocrine/Metabolic Indication: Treat Type II diabetes In a rodent model of Type II diabetes, chronic treatment with JD-5037 improved glycemic control …

    Published on 10/14/2013
  • Metabolic Solutions preclinical data

    Metabolic Solutions Development Co., Kalamazoo, Mich. Product: Mitoglitazone (MSDC-0160) Business: Neurology Indication: Treat Parkinson's disease (PD) In a mouse model of PD, MSDC-0160 improved motor deficits, restored…

    Published on 10/14/2013
  • PharmAthene preclinical data

    PharmAthene Inc. (NYSE-M:PIP), Annapolis, Md. Product: SparVax (Recombinant protective antigen (rPA) anthrax vaccine) Business: Infectious Indication: Prevent anthrax infection In rabbits, doses of intramuscular SparVax…

    Published on 10/14/2013
  • Tekmira preclinical data

    Tekmira Pharmaceuticals Corp. (TSX:TKM; NASDAQ:TKMR), Burnaby, B.C. Product: TKM-Marburg, anti-MARV siRNA Business: Infectious Indication: Treat Marburg virus infection In non-human primates, once-daily 0.5 mg/kg TKM-…

    Published on 10/7/2013
  • Trigemina preclinical data

    Trigemina Inc., Moraga, Calif. Product: Intranasal oxytocin (TI-001) Business: Neurology Indication: Treat trigeminal neuralgia and trigeminal neuropathy In a rat model of trigeminal neuralgia, intranasal TI-001 …

    Published on 9/23/2013
  • Tekmira preclinical data

    Tekmira Pharmaceuticals Corp. (TSX:TKM; NASDAQ:TKMR), Burnaby, B.C. Product: Anti-MARV siRNA Business: Infectious Indication: Treat Marburg virus infection In guinea pigs, Tekmira's anti-MARV siRNAs provided 100% …

    Published on 9/9/2013
  • Alla Chem preclinical data

    Alla Chem LLC, Hallandale Beach, Fla. Product: ONC1-13B Business: Cancer Indication: Treat prostate cancer In vitro and in vivo, ONC1-13B led to greater antitumor activity as calculated per unit of concentration in …

    Published on 9/2/2013
  • Amarantus Bioscience preclinical data

    Amarantus Bioscience Holdings Inc. (OTCQB:AMBS), Sunnyvale, Calif. Product: MANF (Mesencephalic astrocyte-derived neurotrophic factor) (formerly AMRS001) Business: Ophthalmic Indication: Treat retinitis pigmentosa In a …

    Published on 9/2/2013
  • Inovio preclinical data

    Inovio Pharmaceuticals Inc. (NYSE-M:INO), Blue Bell, Pa. Product: SynCon malaria DNA vaccine Business: Infectious Indication: Prevent malaria infection In mice and non-human primates, Inovio's SynCon malaria DNA vaccine…

    Published on 9/2/2013
  • Karyopharm preclinical data

    Karyopharm Therapeutics Inc., Natick, Mass. Product: Selinexor (KPT-330) Business: Cancer Indication: Treat Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) …

    Published on 9/2/2013
  • Pfizer preclinical data

    Pfizer Inc. (NYSE:PFE), New York, N.Y. Product: Sirolimus (Rapamune) Business: Genitourinary Indication: Prevent preterm birth Researchers at Cincinnati Children's Hospital Medical Center and colleagues reported data …

    Published on 9/2/2013
  • Piqur preclinical data

    Piqur Therapeutics AG, Basel, Switzerland Product: PQR-309 Business: Cancer Indication: Treat solid tumors Piqur said PQR-309 led to anti-proliferative activity in vitro and antitumor efficacy in vivo, but could not be …

    Published on 9/2/2013
  • Pluristem Therapeutics preclinical data

    Pluristem Therapeutics Inc. (NASDAQ:PSTI; Tel Aviv:PSTI), Haifa, Israel Product: PLX-PAD cells Business: Musculoskeletal Indication: Treat tendon injury In rat patellar tendons with collagenase-induced injuries, …

    Published on 9/2/2013
  • Retrophin preclinical data

    Retrophin Inc. (OTCQB:RTRX), New York, N.Y. Product: RE-024 Business: Neurology Indication: Treat pantothenate kinase-associated neurodegeneration (PKAN) In mice with a PKAN-like phenotype, RE-024 led to a 92.5% …

    Published on 9/2/2013
  • TheraBiologics, University of Chicago, City of Hope preclinical data

    TheraBiologics Inc., Arcadia, Calif. University of Chicago, Chicago, Ill. City of Hope, Duarte, Calif. Product: TBX-03 Business: Cancer Indication: Treat glioblastoma multiforme (GBM) In a mouse model of GBM, TBX-03 in …

    Published on 9/2/2013
  • Argos, Danaher preclinical data

    Argos Therapeutics Inc., Durham, N.C. Danaher Corp. (NYSE:DHR), Washington, D.C. Product: Soluble CD83 (sCD83) protein Business: Transplant Indication: Prevent transplant rejection In a mouse model of high-risk cornea …

    Published on 8/19/2013
  • Galectin Therapeutics preclinical data

    Galectin Therapeutics Inc. (NASDAQ:GALT), Norcross, Ga. Product: GM-CT-01 (formerly Davanat); GM-MD-02 Business: Pulmonary Indication: Treat idiopathic pulmonary fibrosis In a mouse model of idiopathic pulmonary …

    Published on 8/19/2013
  • Aerpio Therapeutics preclinical data

    Aerpio Therapeutics Inc., Cincinnati, Ohio Product: AKB-9778 Business: Cancer Indication: Treat breast cancer Researchers at Massachusetts General Hospital and colleagues reported data from mouse models of breast cancer…

    Published on 8/12/2013
  • Astex Pharmaceuticals preclinical data

    Astex Pharmaceuticals Inc. (NASDAQ:ASTX), Dublin, Calif. Product: AT13387 Business: Cancer Indication: Treat melanoma In a mouse xenograft model of melanoma with BRAF V600E mutations, AT13387 plus Zelboraf vemurafenib …

    Published on 8/12/2013
  • Biokine, BioLineRx preclinical data

    Biokine Therapeutics Ltd., Tel Aviv, Israel BioLineRx Ltd. (Tel Aviv:BLRX; NASDAQ:BLRX), Jerusalem, Israel Product: BL-8040 (formerly BKT-140) Business: Hematology Indication: Treat thrombocytopenia In healthy and …

    Published on 8/12/2013
  • Elusys preclinical data

    Elusys Therapeutics Inc., Pine Brook, N.J. Product: Anthim (ETI-204) Business: Infectious Indication: Treat and prevent anthrax infection In cynomolgus monkeys exposed to aerosolized Bacillus anthracis spores, a single …

    Published on 8/12/2013
  • Inovio preclinical data

    Inovio Pharmaceuticals Inc. (NYSE-M:INO), Blue Bell, Pa. Product: HIF1-alpha plasmid DNA therapy Business: Cardiovascular Indication: Treat critical limb ischemia (CLI) In a mouse model of limb ischemia, Inovio's …

    Published on 8/12/2013
  • Inovio preclinical data

    Inovio Pharmaceuticals Inc. (NYSE-M:INO), Blue Bell, Pa. Product: HTERT DNA cancer vaccine (INO-1400) Business: Cancer Indication: Treat solid tumors In tumor-bearing mice, animals treated with Inovio's hTERT DNA cancer…

    Published on 8/12/2013
  • Lakewood-Amedex preclinical data

    Lakewood-Amedex Inc., University Park, Fla. Product: Bisphosphocin (Nu-3) Business: Infectious Indication: Treat Klebsiella pneumonia and Escherichia coli infection In vitro, Nu-3 led to a rapid >5 log reduction in …

    Published on 8/12/2013
  • AmpliPhi BioSciences, Celladon preclinical data

    AmpliPhi Biosciences Corp. (Pink:APHB), Richmond, Va. Celladon Corp., San Diego, Calif. Product: Mydicar (AAV1/SERCA2a) Business: Cardiovascular Indication: Treat pulmonary arterial hypertension (PAH) In rat models of …

    Published on 8/5/2013

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