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Chronological Index of : Preclinical Results

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  • Neuroptis preclinical data

    Neuroptis Biotech, Paris, France Product: ML7 Business: Ophthalmic Indication: Treat ocular surface diseases, including dry eye syndrome In rats, pretreatment with an eye drop formulation of ML7 significantly reduced …

    Published on 11/25/2013
  • Revalesio preclinical data

    Revalesio Corp., Tacoma, Wash. Product: RNS60 Business: Neurology Indication: Treat Parkinson's disease (PD) In a mouse model of PD, RNS60 restored dopamine loss, preserved motor function and provided significant …

    Published on 11/25/2013
  • AM-Pharma preclinical data

    AM-Pharma B.V., Bunnik, the Netherlands Product: RecAP (recombinant Alkaline Phosphatase) Business: Renal Indication: Treat acute kidney injury (AKI) In a rat model of AKI, a single dose of 1,000 U/kg IV recAP …

    Published on 11/18/2013
  • Emergent BioSolutions preclinical data

    Emergent BioSolutions Inc. (NYSE:EBS), Rockville, Md. Product: ES414 Business: Cancer Indication: Treat metastatic castration-resistant prostate cancer (CRPC) In a mouse xenograft model of prostate cancer, 3 and 30 g …

    Published on 11/18/2013
  • OncoSec preclinical data

    OncoSec Medical Inc. (OTCQB:ONCS), San Diego, Calif. Product: ImmunoPulse (OMS ElectroImmunotherapy, DNA IL-12) Business: Cancer Indication: Treat melanoma Researchers at Old Dominion University reported data from a …

    Published on 11/4/2013
  • Alnylam, Medicines Co. preclinical data

    Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. The Medicines Co. (NASDAQ:MDCO), Parsippany, N.J. Product: ALN-PCSsc Business: Endocrine/Metabolic Indication: Treat severe hypercholesterolemia In non-human …

    Published on 10/28/2013
  • Alnylam preclinical data

    Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: ALN-AS1 Business: Endocrine/Metabolic Indication: Treat acute intermittent porphyria In a mouse model of acute intermittent porphyria, ALN-AS1 …

    Published on 10/28/2013
  • Compugen preclinical data

    Compugen Ltd. (NASDAQ:CGEN), Tel Aviv, Israel Product: CGEN-15001 Business: Autoimmune Indication: Treat psoriasis In a mouse model of psoriasis, CGEN-15001 was "highly efficient" in preventing disease development in …

    Published on 10/28/2013
  • Compugen preclinical data

    Compugen Ltd. (NASDAQ:CGEN), Tel Aviv, Israel Product: CGEN-15001 Business: Endocrine/Metabolic Indication: Treat Type I diabetes In non-obese mice that spontaneously develop autoimmune insulin-dependent diabetes, CGEN-…

    Published on 10/28/2013
  • Compugen preclinical data

    Compugen Ltd. (NASDAQ:CGEN), Tel Aviv, Israel Product: CGEN-15001 Business: Transplant Indication: Prevent bone marrow transplant rejection In a mouse model of bone marrow transplantation, successful engraftment was …

    Published on 10/28/2013
  • Pluristem Therapeutics preclinical data

    Pluristem Therapeutics Inc. (NASDAQ:PSTI; Tel Aviv:PSTI), Haifa, Israel Product: PLX cells Business: Transplant Indication: Treat graft-versus-host disease (GvHD) In a mouse model of GvHD, intramuscular and IV …

    Published on 10/28/2013
  • Fedora Pharmaceuticals preclinical data

    Fedora Pharmaceuticals Inc., Edmonton, Alberta Product: FPI-1465 Business: Infectious Indication: Treat bacterial infections In Klebsiella pneumoniae-infected mice, 256 mg/kg subcutaneous FPI-1465 plus 1,024 mg/kg …

    Published on 10/14/2013
  • Immunovaccine preclinical data

    Immunovaccine Inc. (TSX-V:IMV), Halifax, Nova Scotia Product: DepoVax, DPX-Anthrax Business: Infectious Indication: Vaccinate against anthrax In rabbits, a single dose of DepoVax containing 5 g of recombinant protective…

    Published on 10/14/2013
  • Jenrin preclinical data

    Jenrin Discovery Inc., West Chester, Pa. Product: JD-5037 Business: Endocrine/Metabolic Indication: Treat Type II diabetes In a rodent model of Type II diabetes, chronic treatment with JD-5037 improved glycemic control …

    Published on 10/14/2013
  • Metabolic Solutions preclinical data

    Metabolic Solutions Development Co., Kalamazoo, Mich. Product: Mitoglitazone (MSDC-0160) Business: Neurology Indication: Treat Parkinson's disease (PD) In a mouse model of PD, MSDC-0160 improved motor deficits, restored…

    Published on 10/14/2013
  • PharmAthene preclinical data

    PharmAthene Inc. (NYSE-M:PIP), Annapolis, Md. Product: SparVax (Recombinant protective antigen (rPA) anthrax vaccine) Business: Infectious Indication: Prevent anthrax infection In rabbits, doses of intramuscular SparVax…

    Published on 10/14/2013
  • Tekmira preclinical data

    Tekmira Pharmaceuticals Corp. (TSX:TKM; NASDAQ:TKMR), Burnaby, B.C. Product: TKM-Marburg, anti-MARV siRNA Business: Infectious Indication: Treat Marburg virus infection In non-human primates, once-daily 0.5 mg/kg TKM-…

    Published on 10/7/2013
  • Trigemina preclinical data

    Trigemina Inc., Moraga, Calif. Product: Intranasal oxytocin (TI-001) Business: Neurology Indication: Treat trigeminal neuralgia and trigeminal neuropathy In a rat model of trigeminal neuralgia, intranasal TI-001 …

    Published on 9/23/2013
  • Tekmira preclinical data

    Tekmira Pharmaceuticals Corp. (TSX:TKM; NASDAQ:TKMR), Burnaby, B.C. Product: Anti-MARV siRNA Business: Infectious Indication: Treat Marburg virus infection In guinea pigs, Tekmira's anti-MARV siRNAs provided 100% …

    Published on 9/9/2013
  • Alla Chem preclinical data

    Alla Chem LLC, Hallandale Beach, Fla. Product: ONC1-13B Business: Cancer Indication: Treat prostate cancer In vitro and in vivo, ONC1-13B led to greater antitumor activity as calculated per unit of concentration in …

    Published on 9/2/2013
  • Amarantus Bioscience preclinical data

    Amarantus Bioscience Holdings Inc. (OTCQB:AMBS), Sunnyvale, Calif. Product: MANF (Mesencephalic astrocyte-derived neurotrophic factor) (formerly AMRS001) Business: Ophthalmic Indication: Treat retinitis pigmentosa In a …

    Published on 9/2/2013
  • Inovio preclinical data

    Inovio Pharmaceuticals Inc. (NYSE-M:INO), Blue Bell, Pa. Product: SynCon malaria DNA vaccine Business: Infectious Indication: Prevent malaria infection In mice and non-human primates, Inovio's SynCon malaria DNA vaccine…

    Published on 9/2/2013
  • Karyopharm preclinical data

    Karyopharm Therapeutics Inc., Natick, Mass. Product: Selinexor (KPT-330) Business: Cancer Indication: Treat Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) …

    Published on 9/2/2013
  • Pfizer preclinical data

    Pfizer Inc. (NYSE:PFE), New York, N.Y. Product: Sirolimus (Rapamune) Business: Genitourinary Indication: Prevent preterm birth Researchers at Cincinnati Children's Hospital Medical Center and colleagues reported data …

    Published on 9/2/2013
  • Piqur preclinical data

    Piqur Therapeutics AG, Basel, Switzerland Product: PQR-309 Business: Cancer Indication: Treat solid tumors Piqur said PQR-309 led to anti-proliferative activity in vitro and antitumor efficacy in vivo, but could not be …

    Published on 9/2/2013

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