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Chronological Index of : Preclinical Results

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  • SomaLogic, Otsuka Pharmaceutical preclinical data

    SomaLogic Inc., Boulder, Colo. Otsuka Pharmaceutical Co. Ltd., Tokyo, Japan Product: SL1026 Business: Autoimmune Indication: Treat rheumatoid arthritis (RA) In cynomolgus monkeys, SL1026 significantly delayed the onset …

    Published on 1/11/2016
  • Acetylon preclinical data

    Acetylon Pharmaceuticals Inc., Boston, Mass. Product: ACY-957 Business: Hematology Indication: Treat beta thalassemia In rats and monkeys, once-daily oral ACY-957 increased hemoglobin subunit epsilon 1 (HBE1; HBE) and …

    Published on 12/21/2015
  • Phrixus preclinical data

    Phrixus Pharmaceuticals Inc., Ann Arbor, Mich. Product: Subcutaneous poloxamer 188 (Carmeseal-MD, Carmeseal) (P-188 NF) Business: Cardiovascular Indication: Treat heart failure in Duchenne muscular dystrophy (DMD) …

    Published on 11/16/2015
  • Arno preclinical data

    Arno Therapeutics Inc. (OTCQB:ARNI), Flemington, N.J. Product: AR-13 Business: Infectious Indication: Treat acute and chronic antibiotic-resistant bacterial infections in patients with cystic fibrosis (CF) In human CF …

    Published on 11/2/2015
  • Kuros preclinical data

    Kuros Biosurgery AG, Zurich, Switzerland Product: KUR-115 Business: Musculoskeletal Indication: Lumbar interbody spinal fusion treatment In skeletally mature sheep undergoing lumbar interbody spinal athrodesis, 0.4 mg/…

    Published on 11/2/2015
  • Probiodrug preclinical data

    Probiodrug AG (Euronext:PBD), Halle/Saale, Germany Product: Pyroglutamate-3 beta amyloid mAb Business: Neurology Indication: Treat Alzheimers disease (AD) In a mouse model of AD, passive immunization with Probiodrugs …

    Published on 11/2/2015
  • Alnylam preclinical data

    Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: ALN-TTRsc02 Business: Endocrine/Metabolic Indication: Treat transthyretin (TTR)-mediated amyloidosis In non-human primates, a single dose of 1 mg/kg …

    Published on 10/19/2015
  • AmpliPhi BioSciences preclinical data

    AmpliPhi Biosciences Corp. (NYSE-M:APHB), Richmond, Va. Product: Bacteriophage cocktail Business: Infectious Indication: Treat Staphylococcus aureus lung infection In neutropenic, immunocompromised mice inoculated with …

    Published on 10/19/2015
  • Arbutus Biopharma preclinical data

    Arbutus Biopharma Corp. (NASDAQ:ABUS), Burnaby, B.C. Product: TKM-HBV Business: Infectious Indication: Treat chronic HBV infection In a mouse model of HBV infection, 4 weekly doses of 0.3 mg/kg TKM-HBV reduced HBV …

    Published on 10/12/2015
  • Biogen, Applied Genetic Technologies preclinical data

    Biogen Inc. (NASDAQ:BIIB), Cambridge, Mass. Applied Genetic Technologies Corp. (NASDAQ:AGTC), Alachua, Fla. Product: rAAV2tYF-CB-hRS1 Business: Ophthalmic Indication: Treat X-linked retinoschisis (XLRS) In retinoschisis…

    Published on 10/12/2015
  • F-star Alpha, Bristol-Myers preclinical data

    F-star Alpha Ltd., Cambridge, U.K. Bristol-Myers Squibb Co. (NYSE:BMY), New York, N.Y. Product: FS102 Business: Cancer Indication: Treat HER2-positive cancer In mouse models of HER2-positive colorectal or gastric cancer…

    Published on 10/12/2015
  • Kolltan preclinical data

    Kolltan Pharmaceuticals Inc., New Haven, Conn. Product: KTN0158 Business: Cancer Indication: Treat cancer In 12 evaluable dogs with spontaneous mast cell tumors, KTN0158 led to 5 partial responses and 7 cases of stable …

    Published on 10/12/2015
  • Microlin Bio preclinical data

    Microlin Bio Inc., New York, N.Y. Product: Lumiralin (AM-21) Business: Cancer Indication: Treat lung cancer In a mouse xenograft model of lung cancer, thrice-weekly 1 mg/kg IV AM-21 for 1 week followed by once-weekly AM…

    Published on 10/12/2015
  • Pernix Therapeutics preclinical data

    Pernix Therapeutics Holdings Inc. (NASDAQ:PTX), Morristown, N.J. Product: ZX007 Business: Neurology Indication: Treat moderate to severe chronic pain In vitro studies with ZX007 showed that the abuse-deterrent tablet …

    Published on 10/12/2015
  • Protalix preclinical data

    Protalix BioTherapeutics Inc. (NYSE-M:PLX; Tel Aviv:PLX), Carmiel, Israel Product: Oral antiTNF, pr-antiTNF (PRX-106) Business: Hepatic Indication: Treat non-alcoholic steatohepatitis (NASH) In an inflammatory mouse …

    Published on 10/12/2015
  • Acceleron Pharma Inc preclinical data

    Acceleron Pharma Inc. (NASDAQ:XLRN), Cambridge, Mass. Product: ACE-2494 Business: Musculoskeletal Indication: Increase muscle mass and strength In mice, twice-weekly 10 mg/kg subcutaneous ACE-2494 increased muscle mass …

    Published on 10/5/2015
  • Acceleron Pharma Inc preclinical data

    Acceleron Pharma Inc. (NASDAQ:XLRN), Cambridge, Mass. Product: ACE-083 Business: Musculoskeletal Indication: Increase muscle mass and strength In mice, twice-weekly 100 ug ACE-083 injected into the right tibialis …

    Published on 10/5/2015
  • Cidara Therapeutics preclinical data

    Cidara Therapeutics Inc. (NASDAQ:CDTX), San Diego, Calif. Product: CD101 IV (formerly Biafungin, SP 3025) Business: Infectious Indication: Treat invasive candidiasis In mice infected with echinocandin-susceptible wild-…

    Published on 9/28/2015
  • Infinity preclinical data

    Infinity Pharmaceuticals Inc. (NASDAQ:INFI), Cambridge, Mass. Product: IPI-549 Business: Cancer Indication: Treat solid tumors In mouse models of solid tumors, IPI-549 reduced tumor-associated myeloid cells found in the…

    Published on 9/28/2015
  • Matinas BioPharma preclinical data

    Matinas BioPharma Holdings Inc. (OTCQB:MTNB), Bedminster, N.J. Product: C-Amikacin (MAT2501) Business: Infectious Indication: Treat Gram-negative bacterial infections In mice infected with Mycobacterium avium, 100 mg/kg…

    Published on 9/28/2015
  • Scholar Rock preclinical data

    Scholar Rock LLC, Cambridge, Mass. Product: SRK-015 Business: Musculoskeletal Indication: Treat primary myopathies In vitro, SRK-015 bound latent myostatin (MSTN; GDF8) with nanomolar affinity and inhibited its …

    Published on 9/28/2015
  • Taxis Pharmaceuticals preclinical data

    Taxis Pharmaceuticals Inc., North Brunswick, N.J. Product: TXA709 Business: Infectious Indication: Treat methicillin-resistant Staphylococcus aureus (MRSA) infection Taxis said oral TXA709 plus cefdinir showed …

    Published on 9/28/2015
  • Alnylam preclinical data

    Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: ALN-GO1 Business: Endocrine/Metabolic Indication: Treat primary hyperoxaluria (PH1) In a rat model of PH1, once-weekly subcutaneous ALN-GO1 reduced …

    Published on 9/21/2015
  • GeoVax Labs preclinical data

    GeoVax Labs Inc. (OTCBB:GOVX), Atlanta, Ga. Product: GOVX-E301 Business: Infectious Indication: Vaccinate against Ebola virus infection In guinea pigs and hamsters, GOVX-E301 conferred 100% protection against Ebola …

    Published on 9/21/2015
  • TxCell preclinical data

    TxCell S.A. (Euronext:TXCL), Valbonne, France Product: Col-Treg Business: Ophthalmic Indication: Treat non-infectious uveitis In an animal model of non-infectious uveitis, IV Col-Treg significantly inhibited clinical …

    Published on 9/21/2015

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