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Chronological Index of : Preclinical Results

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  • Addex preclinical data

    Addex Therapeutics Ltd. (SIX:ADXN), Geneva, Switzerland Product: ADX71441 Business: Neurology Indication: Treat nicotine addiction In nicotine-dependent mice, 1, 3 and 10 mg/kg oral ADX71441 administered 60 minutes …

    Published on 8/11/2014
  • Vertex preclinical data

    Vertex Pharmaceuticals Inc. (NASDAQ:VRTX), Boston, Mass. Product: Lumacaftor (VX-809) Business: Pulmonary Indication: Treat cystic fibrosis (CF) Data from a pair of in vitro studies published in Science Translational …

    Published on 7/28/2014
  • ImStem Biotechnology preclinical data

    ImStem Biotechnology Inc., Farmington, Conn. Product: HES-MSCs Business: Autoimmune Indication: Treat multiple sclerosis (MS) In an animal model of MS, human embryonic stem cell-derived mesenchymal stem cells (hES-MSCs)…

    Published on 7/21/2014
  • La Jolla Pharmaceutical preclinical data

    La Jolla Pharmaceutical Co. (NASDAQ:LJPC), San Diego, Calif. Product: LJPC-1010 Business: Hepatic Indication: Treat non-alcoholic steatohepatitis (NASH) In a mouse model of NASH, oral LJPC-1010 significantly reduced non…

    Published on 7/21/2014
  • Blueprint Medicines preclinical data

    Blueprint Medicines, Cambridge, Mass. Product: BLU9931 Business: Cancer Indication: Treat hepatocellular carcinoma (HCC) In mouse xenograft models of fibroblast growth factor 19 (FGF19) amplified and FGF19 …

    Published on 4/21/2014
  • Celldex preclinical data

    Celldex Therapeutics Inc. (NASDAQ:CLDX), Needham, Mass. Product: CDX-014 (formerly CR014-vcMMAE) Business: Cancer Indication: Treat ovarian cancer and renal cell carcinoma (RCC) In mouse xenograft models of ovarian …

    Published on 4/21/2014
  • Genkyotex preclinical data

    Genkyotex S.A., Plan-les-Ouates, Switzerland Product: GKT137831 Business: Pulmonary Indication: Treat idiopathic pulmonary fibrosis (IPF) In aged mice with established pulmonary fibrosis, GKT137831 led to a reversal of …

    Published on 4/21/2014
  • MacroGenics preclinical data

    MacroGenics Inc. (NASDAQ:MGNX), Rockville, Md. Product: MGD007 Business: Cancer Indication: Treat colorectal cancer In a mouse xenograft model of colorectal cancer, doses as low as 4 g/kg IV MGD007 inhibited tumor …

    Published on 4/21/2014
  • NanoAntibiotics preclinical data

    NanoAntibiotics Inc., Surfside, Fla. Product: Efflux pump inhibitor Business: Infectious Indication: Treat bacterial infections In Staphylococcus epidermis bacteria incubated in vitro with tracer dye to monitor the …

    Published on 4/21/2014
  • OncoMed preclinical data

    OncoMed Pharmaceuticals Inc. (NASDAQ:OMED), Redwood City, Calif. Product: OMP-305B83 Business: Cancer Indication: Treat solid tumors OncoMed said OMP-305B83 showed significant in vivo antitumor efficacy in various solid…

    Published on 4/21/2014
  • Onconova Therapeutics preclinical data

    Onconova Therapeutics Inc. (NASDAQ:ONTX), Newton, Pa. Product: ON 1233000 Business: Cancer Indication: Treat mantle cell lymphoma (MCL) and multiple myeloma (MM) In a mouse xenograft model of MCL, once-daily 100 mg/kg …

    Published on 4/21/2014
  • OxiGene preclinical data

    OxiGene Inc. (NASDAQ:OXGN), South San Francisco, Calif. Product: KGP94 Business: Cancer Indication: Treat squamous cell carcinoma of the head and neck (SCCHN) In a mouse model of SCCHN, KGP94 significantly delayed tumor…

    Published on 4/21/2014
  • Regulus preclinical data

    Regulus Therapeutics Inc. (NASDAQ:RGLS), San Diego, Calif. Product: Anti-miR-221 Business: Cancer Indication: Treat hepatocellular cancer (HCC) In a mouse xenograft model of HCC, thrice-weekly subcutaneous 25 mg/kg anti…

    Published on 4/21/2014
  • Seattle Genetics preclinical data

    Seattle Genetics Inc. (NASDAQ:SGEN), Bothell, Wash. Product: SGN-CD70A Business: Cancer Indication: Treat cancer In renal cell carcinoma (RCC) and non-Hodgkin's lymphoma (NHL) cell lines, SGN-CD70A induced targeted cell…

    Published on 4/21/2014
  • TherapeuticsMD preclinical data

    TherapeuticsMD Inc. (NYSE-M:TXMD), Boca Raton, Fla. Product: Estradiol VagiCap (TX-004HR) (formerly TX 12-004-HR) Business: Endocrine/Metabolic Indication: Treat moderate to severe symptoms of vulvar and vaginal atrophy…

    Published on 4/21/2014
  • BerGenBio, Rigel preclinical data

    BerGenBio A/S, Bergen, Norway Rigel Pharmaceuticals Inc. (NASDAQ:RIGL), South San Francisco, Calif. Product: BGB324 (formerly R428) Business: Cancer Indication: Treat chronic myelogenous leukemia (CML) In a mouse model …

    Published on 1/20/2014
  • MacroGenics preclinical data

    MacroGenics Inc. (NASDAQ:MGNX), Rockville, Md. Product: MGD006 (CD3xCD123 DART molecule) Business: Cancer Indication: Treat acute myelogenous leukemia (AML) In mice infused with primary AML xenografts, MGD006 led to a &…

    Published on 1/20/2014
  • Teva, Sanofi preclinical data

    Teva Pharmaceutical Industries Ltd. (NYSE:TEVA), Petah Tikva, Israel Sanofi (Euronext:SAN; NYSE:SNY), Paris, France Product: Copaxone glatiramer acetate Business: Autoimmune Indication: Treat multiple sclerosis (MS) A …

    Published on 1/20/2014
  • Neumedicines preclinical data

    Neumedicines Inc., Pasadena, Calif. Product: HemaMax (NMIL 12-1) Business: Other Indication: Treat acute radiation syndrome (ARS) In non-human primates, a single low-dose subcutaneous injection of HemaMax significantly …

    Published on 1/13/2014
  • Alnylam preclinical data

    Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: ALN-ANG Business: Endocrine/Metabolic Indication: Treat genetic forms of mixed hyperlipidemia and severe hypertriglyceridemia In a mouse model of …

    Published on 1/6/2014
  • Novogen preclinical data

    Novogen Ltd. (ASX:NRT; NASDAQ:NVGN), Hornsby, Australia Product: Trilexium Business: Cancer Indication: Treat ovarian cancer In vitro, Trilexium destroyed ovarian cancer spheroid architecture. Novogen said cancer stem …

    Published on 1/6/2014
  • Tekmira preclinical data

    Tekmira Pharmaceuticals Corp. (TSX:TKM; NASDAQ:TKMR), Burnaby, B.C. Product: TKM-Ebola (TKM-100201) (formerly Ebola SNALP) Business: Infectious Indication: Treat Ebola virus infection In non-human primates, once-daily 0…

    Published on 1/6/2014
  • Flatley Discovery Lab preclinical data

    Flatley Discovery Lab LLC, Charlestown, Mass. Product: FDL169 Business: Pulmonary Indication: Treat cystic fibrosis (CF) In ex vivo human primary bronchial epithelial cells from CF patients homozygous for the delta F508…

    Published on 11/25/2013
  • iPierian preclinical data

    iPierian Inc., South San Francisco, Calif. Product: IPN007 Business: Neurology Indication: Treat Alzheimer's disease (AD) In a mouse model of tauopathy, a mouse formulation of IPN007 for 6 months inhibited global …

    Published on 11/25/2013
  • Neuroptis preclinical data

    Neuroptis Biotech, Paris, France Product: ML7 Business: Ophthalmic Indication: Treat ocular surface diseases, including dry eye syndrome In rats, pretreatment with an eye drop formulation of ML7 significantly reduced …

    Published on 11/25/2013

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