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Chronological Index of : Preclinical Results

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  • Zealand Pharma preclinical data

    Zealand Pharma A/S (CSE:ZEAL), Glostrup, Denmark Product: ZP-DI-70 Business: Endocrine/Metabolic Indication: Treat Type II diabetes In a mouse model of obesity, subcutaneous ZP-DI-70 every 3 days for 18 days reduced …

    Published on 6/29/2015
  • Fibrocell, Intrexon preclinical data

    Fibrocell Science Inc. (NASDAQ:FCSC), Exton, Pa. Intrexon Corp. (NYSE:XON), Germantown, Md. Product: FCX-007 Business: Dermatology Indication: Treat recessive dystrophic epidermolysis bullosa (RDEB) In severe combined …

    Published on 6/15/2015
  • Applied Genetic Technologies, Pfizer preclinical data

    Applied Genetic Technologies Corp. (NASDAQ:AGTC), Alachua, Fla. Pfizer Inc. (NYSE:PFE), New York, N.Y. Product: AAV-hCNGB3 Business: Ophthalmic Indication: Treat achromatopsia In dogs with achromatopsia, AAV-hCNGB3 led …

    Published on 5/18/2015
  • Isarna Therapeutics preclinical data

    Isarna Therapeutics GmbH, Munich, Germany Product: ISTH0036 Business: Ophthalmic Indication: Treat open-angle glaucoma In a mouse model of glaucoma filtration surgery, intraocular ISTH0036 significantly improved bleb …

    Published on 5/18/2015
  • Advanced Proteome Therapeutics preclinical data

    Advanced Proteome Therapeutics Corp. (TSX-V:APC; FSE:0E8), Boston, Mass. Product: APC 101 Business: Cancer Indication: Treat breast cancer In a mouse model of breast cancer, APC 101 reduced metastases to the lungs. APC …

    Published on 5/11/2015
  • Mersana preclinical data

    Mersana Therapeutics Inc., Cambridge, Mass. Product: XMT-1522 Business: Cancer Indication: Treat HER2-positive solid tumors In mouse xenograft models of HER2-positive gastric and breast cancer, single doses of <=1 mg…

    Published on 5/11/2015
  • NGM Biopharmaceuticals preclinical data

    NGM Biopharmaceuticals Inc., South San Francisco, Calif. Product: NGM282 Business: Hepatic Indication: Treat non-alcoholic steatohepatitis (NASH) In a mouse model of NASH, NGM282 significantly reduced total body weight,…

    Published on 5/11/2015
  • Novogen, Yale University preclinical data

    Novogen Ltd. (ASX:NRT; NASDAQ:NVGN), Hornsby, Australia Yale University, New Haven, Conn. Product: Cantrixil Business: Cancer Indication: Treat ovarian cancer In a mouse model of ovarian cancer, 100 mg/kg …

    Published on 5/11/2015
  • Revive Therapeutics preclinical data

    Revive Therapeutics Ltd. (TSX-V:RVV), Vaughan, Ontario Product: Tianeptine (REV-003) Business: Neurology Indication: Treat Rett syndrome In a mouse model of Rett syndrome, REV-003 improved motor coordination and gait …

    Published on 5/11/2015
  • Tamir preclinical data

    Tamir Biotechnology Inc., San Diego, Calif. Product: TMR004 Business: Infectious Indication: Treat Ebola virus infection In mice infected with Ebola virus, intraperitoneal TMR004 led to a survival rate of 70-80% vs. 0% …

    Published on 5/11/2015
  • Blueprint Medicines preclinical data

    Blueprint Medicines Corp., Cambridge, Mass. Product: BLU-285 Business: Cancer Indication: Treat gastrointestinal stromal tumors (GIST) In a mouse model of treatment-refractory GIST, once-daily 30 and 100 mg/kg oral BLU-…

    Published on 4/27/2015
  • Momenta Pharmaceuticals Inc, Novartis preclinical data

    Momenta Pharmaceuticals Inc. (NASDAQ:MNTA), Cambridge, Mass. Novartis AG (NYSE:NVS; SIX:NOVN), Basel, Switzerland Product: Glatiramer acetate (Glatopa) (M356) Business: Autoimmune Indication: Treat relapsing forms of …

    Published on 4/27/2015
  • PhaseBio preclinical data

    PhaseBio Pharmaceuticals Inc., Malvern, Pa. Product: Vasomera (PB1046) Business: Musculoskeletal Indication: Treat Duchenne muscular dystrophy (DMD) In a mouse model of DMD, thrice-weekly 1.5 mg/kg subcutaneous PB1046 …

    Published on 4/27/2015
  • BioInvent International A preclinical data

    BioInvent International AB (SSE:BINV), Lund, Sweden Product: BI-1206 Business: Cancer Indication: Treat lymphoma In mice, BI-1206 prevented tumor cell internalization of Rituxan rituximab, a chimeric mAb against CD20 …

    Published on 4/20/2015
  • AstraZeneca pl preclinical data

    AstraZeneca plc (LSE:AZN; NYSE:AZN), London, U.K. Product: Saracatinib (AZD0530) Business: Neurology Indication: Treat Alzheimers disease (AD) In a mouse model of AD, saracatinib for 4 weeks led to complete reversal of …

    Published on 4/13/2015
  • Batu Biologics preclinical data

    Batu Biologics Inc., San Diego, Calif. Product: ValloVax Business: Cancer Indication: Treat solid tumors In mouse models of melanoma, breast cancer and Lewis lung carcinoma (LLC), once-weekly subcutaneous ValloVax for 4…

    Published on 4/13/2015
  • BioBlast Pharma Ltd preclinical data

    BioBlast Pharma Ltd. (NASDAQ:ORPN), Tel Aviv, Israel Product: BB-FA Business: Neurology Indication: Treat Friedreichs ataxia In a mouse model of Friedreichs ataxia, BB-FA rescued brain and heart tissues by returning …

    Published on 4/13/2015
  • Novavax Inc preclinical data

    Novavax Inc. (NASDAQ:NVAX), Gaithersburg, Md. Product: EBOV GP vaccine, Ebola GP Vaccine Business: Infectious Indication: Prevent Ebola virus infection In non-human primates, 2 injections of 5 ug EBOV GP vaccine plus …

    Published on 4/13/2015
  • Profectus preclinical data

    Profectus BioSciences Inc., Baltimore, Md. Product: VesiculoVax Ebola vaccine Business: Infectious Indication: Prevent Ebola virus infection In rhesus macaques, a single dose of Profectus VesiculoVax Ebola vaccine given…

    Published on 4/13/2015
  • Airmid, Kineta preclinical data

    Airmid Inc., Redwood City, Calif. Kineta Inc., Seattle, Wash. Product: ShK-186 Business: Ophthalmic Indication: Treat anterior uveitis In a rat model of anterior uveitis, topical ShK-186 reduced disease severity and …

    Published on 4/6/2015
  • Anavex Life Sciences Corp preclinical data

    Anavex Life Sciences Corp. (OTCQX:AVXL), New York, N.Y. Product: ANAVEX 3-71 (formerly AF710B) Business: Neurology Indication: Treat Alzheimers disease (AD) In a mouse model of AD, ANAVEX 3-71 reversed synaptic loss in …

    Published on 3/30/2015
  • GlycoMimetics Inc preclinical data

    GlycoMimetics Inc. (NASDAQ:GLYC), Gaithersburg, Md. Product: GMI-1359 Business: Cancer Indication: Treat cancer In a mouse model of pancreatic cancer, intraperitoneal GMI-1359 plus gemcitabine significantly reduced …

    Published on 3/30/2015
  • Scancell Holdings pl preclinical data

    Scancell Holdings plc (LSE:SCLP; Xetra:SCP), Nottingham, U.K. Product: SCIB2 Business: Cancer Indication: Treat melanoma In a mouse model of melanoma, SCIB2 plus a murine CTLA-4 (CD152) immune checkpoint inhibitor …

    Published on 3/30/2015
  • BioLineRx, JHL Biotech preclinical data

    BioLineRx Ltd.(Tel Aviv:BLRX; NASDAQ:BLRX), Jerusalem, Israel JHL Biotech Inc., Zhubei, Taiwan Product: BL-9020 Business: Endocrine/Metabolic Indication: Treat Type I diabetes In a mouse model of diabetes, short-term …

    Published on 3/16/2015
  • BrainStorm preclinical data

    BrainStorm Cell Therapeutics Inc. (NASDAQ:BCLI), New York, N.Y. Product: NurOwn (MSC-NTF cells) (formerly Neurotrophic Factor Cells) Business: Neurology Indication: Treat autism In a mouse model of autism, a single …

    Published on 2/9/2015

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