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Chronological Index of : Preclinical Results

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  • Vertex preclinical data

    Vertex Pharmaceuticals Inc. (NASDAQ:VRTX), Boston, Mass. Product: Lumacaftor (VX-809) Business: Pulmonary Indication: Treat cystic fibrosis (CF) Data from a pair of in vitro studies published in Science Translational …

    Published on 7/28/2014
  • ImStem Biotechnology preclinical data

    ImStem Biotechnology Inc., Farmington, Conn. Product: HES-MSCs Business: Autoimmune Indication: Treat multiple sclerosis (MS) In an animal model of MS, human embryonic stem cell-derived mesenchymal stem cells (hES-MSCs)…

    Published on 7/21/2014
  • La Jolla Pharmaceutical preclinical data

    La Jolla Pharmaceutical Co. (NASDAQ:LJPC), San Diego, Calif. Product: LJPC-1010 Business: Hepatic Indication: Treat non-alcoholic steatohepatitis (NASH) In a mouse model of NASH, oral LJPC-1010 significantly reduced non…

    Published on 7/21/2014
  • BerGenBio, Rigel preclinical data

    BerGenBio A/S, Bergen, Norway Rigel Pharmaceuticals Inc. (NASDAQ:RIGL), South San Francisco, Calif. Product: BGB324 (formerly R428) Business: Cancer Indication: Treat chronic myelogenous leukemia (CML) In a mouse model …

    Published on 1/20/2014
  • MacroGenics preclinical data

    MacroGenics Inc. (NASDAQ:MGNX), Rockville, Md. Product: MGD006 (CD3xCD123 DART molecule) Business: Cancer Indication: Treat acute myelogenous leukemia (AML) In mice infused with primary AML xenografts, MGD006 led to a &…

    Published on 1/20/2014
  • Teva, Sanofi preclinical data

    Teva Pharmaceutical Industries Ltd. (NYSE:TEVA), Petah Tikva, Israel Sanofi (Euronext:SAN; NYSE:SNY), Paris, France Product: Copaxone glatiramer acetate Business: Autoimmune Indication: Treat multiple sclerosis (MS) A …

    Published on 1/20/2014
  • Neumedicines preclinical data

    Neumedicines Inc., Pasadena, Calif. Product: HemaMax (NMIL 12-1) Business: Other Indication: Treat acute radiation syndrome (ARS) In non-human primates, a single low-dose subcutaneous injection of HemaMax significantly …

    Published on 1/13/2014
  • Alnylam preclinical data

    Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: ALN-ANG Business: Endocrine/Metabolic Indication: Treat genetic forms of mixed hyperlipidemia and severe hypertriglyceridemia In a mouse model of …

    Published on 1/6/2014
  • Novogen preclinical data

    Novogen Ltd. (ASX:NRT; NASDAQ:NVGN), Hornsby, Australia Product: Trilexium Business: Cancer Indication: Treat ovarian cancer In vitro, Trilexium destroyed ovarian cancer spheroid architecture. Novogen said cancer stem …

    Published on 1/6/2014
  • Tekmira preclinical data

    Tekmira Pharmaceuticals Corp. (TSX:TKM; NASDAQ:TKMR), Burnaby, B.C. Product: TKM-Ebola (TKM-100201) (formerly Ebola SNALP) Business: Infectious Indication: Treat Ebola virus infection In non-human primates, once-daily 0…

    Published on 1/6/2014
  • Flatley Discovery Lab preclinical data

    Flatley Discovery Lab LLC, Charlestown, Mass. Product: FDL169 Business: Pulmonary Indication: Treat cystic fibrosis (CF) In ex vivo human primary bronchial epithelial cells from CF patients homozygous for the delta F508…

    Published on 11/25/2013
  • iPierian preclinical data

    iPierian Inc., South San Francisco, Calif. Product: IPN007 Business: Neurology Indication: Treat Alzheimer's disease (AD) In a mouse model of tauopathy, a mouse formulation of IPN007 for 6 months inhibited global …

    Published on 11/25/2013
  • Neuroptis preclinical data

    Neuroptis Biotech, Paris, France Product: ML7 Business: Ophthalmic Indication: Treat ocular surface diseases, including dry eye syndrome In rats, pretreatment with an eye drop formulation of ML7 significantly reduced …

    Published on 11/25/2013
  • Revalesio preclinical data

    Revalesio Corp., Tacoma, Wash. Product: RNS60 Business: Neurology Indication: Treat Parkinson's disease (PD) In a mouse model of PD, RNS60 restored dopamine loss, preserved motor function and provided significant …

    Published on 11/25/2013
  • AM-Pharma preclinical data

    AM-Pharma B.V., Bunnik, the Netherlands Product: RecAP (recombinant Alkaline Phosphatase) Business: Renal Indication: Treat acute kidney injury (AKI) In a rat model of AKI, a single dose of 1,000 U/kg IV recAP …

    Published on 11/18/2013
  • Emergent BioSolutions preclinical data

    Emergent BioSolutions Inc. (NYSE:EBS), Rockville, Md. Product: ES414 Business: Cancer Indication: Treat metastatic castration-resistant prostate cancer (CRPC) In a mouse xenograft model of prostate cancer, 3 and 30 g …

    Published on 11/18/2013
  • OncoSec preclinical data

    OncoSec Medical Inc. (OTCQB:ONCS), San Diego, Calif. Product: ImmunoPulse (OMS ElectroImmunotherapy, DNA IL-12) Business: Cancer Indication: Treat melanoma Researchers at Old Dominion University reported data from a …

    Published on 11/4/2013
  • Alnylam, Medicines Co. preclinical data

    Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. The Medicines Co. (NASDAQ:MDCO), Parsippany, N.J. Product: ALN-PCSsc Business: Endocrine/Metabolic Indication: Treat severe hypercholesterolemia In non-human …

    Published on 10/28/2013
  • Alnylam preclinical data

    Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: ALN-AS1 Business: Endocrine/Metabolic Indication: Treat acute intermittent porphyria In a mouse model of acute intermittent porphyria, ALN-AS1 …

    Published on 10/28/2013
  • Compugen preclinical data

    Compugen Ltd. (NASDAQ:CGEN), Tel Aviv, Israel Product: CGEN-15001 Business: Autoimmune Indication: Treat psoriasis In a mouse model of psoriasis, CGEN-15001 was "highly efficient" in preventing disease development in …

    Published on 10/28/2013
  • Compugen preclinical data

    Compugen Ltd. (NASDAQ:CGEN), Tel Aviv, Israel Product: CGEN-15001 Business: Endocrine/Metabolic Indication: Treat Type I diabetes In non-obese mice that spontaneously develop autoimmune insulin-dependent diabetes, CGEN-…

    Published on 10/28/2013
  • Compugen preclinical data

    Compugen Ltd. (NASDAQ:CGEN), Tel Aviv, Israel Product: CGEN-15001 Business: Transplant Indication: Prevent bone marrow transplant rejection In a mouse model of bone marrow transplantation, successful engraftment was …

    Published on 10/28/2013
  • Pluristem Therapeutics preclinical data

    Pluristem Therapeutics Inc. (NASDAQ:PSTI; Tel Aviv:PSTI), Haifa, Israel Product: PLX cells Business: Transplant Indication: Treat graft-versus-host disease (GvHD) In a mouse model of GvHD, intramuscular and IV …

    Published on 10/28/2013
  • Fedora Pharmaceuticals preclinical data

    Fedora Pharmaceuticals Inc., Edmonton, Alberta Product: FPI-1465 Business: Infectious Indication: Treat bacterial infections In Klebsiella pneumoniae-infected mice, 256 mg/kg subcutaneous FPI-1465 plus 1,024 mg/kg …

    Published on 10/14/2013
  • Immunovaccine preclinical data

    Immunovaccine Inc. (TSX-V:IMV), Halifax, Nova Scotia Product: DepoVax, DPX-Anthrax Business: Infectious Indication: Vaccinate against anthrax In rabbits, a single dose of DepoVax containing 5 g of recombinant protective…

    Published on 10/14/2013

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