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Cellerant Therapeutics Inc., San Carlos, Calif. Product: Myeloid Progenitor (MP) Cells (CLT-008) Business: Other Indication: Treat acute radiation exposure In mice irradiated with lethal doses of radiation, IV allogenic…
Published on 5/21/2012
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Idera Pharmaceuticals Inc. (NASDAQ:IDRA), Cambridge, Mass. Product: IMO-8400 Business: Autoimmune Indication: Treat lupus In a mouse model of lupus, 150 and 300 g subcutaneous IMO-8400 significantly reduced serum …
Published on 5/21/2012
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Idera Pharmaceuticals Inc. (NASDAQ:IDRA), Cambridge, Mass. Product: IMO-8400 Business: Autoimmune Indication: Treat psoriasis In a mouse model of psoriasis, 300 g subcutaneous IMO-8400 significantly reduced skin …
Published on 5/21/2012
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Mucosis B.V., Groningen, the Netherlands Product: FluGEM Business: Infectious Indication: Prevent influenza infection In mice, Mucosis' FluGEM vaccine provided full protection against homologous and heterologous …
Published on 5/21/2012
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Peregrine Pharmaceuticals Inc. (NASDAQ:PPHM), Tustin, Calif. Product: PGN632 Business: Infectious Indication: Treat herpetic keratitis In a rabbit model of acute herpes simplex virus type 1 (HSV-1) keratitis, PGN632 …
Published on 5/21/2012
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Peregrine Pharmaceuticals Inc. (NASDAQ:PPHM), Tustin, Calif. Product: PGN632 Business: Ophthalmic Indication: Treat age-related macular degeneration (AMD) In a mouse model of AMD, intravitreal PGN632 significantly …
Published on 5/21/2012
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Pluristem Therapeutics Inc. (NASDAQ:PSTI; Tel Aviv:PSTI), Haifa, Israel Product: PLX cells Business: Cardiovascular Indication: Treat diastolic heart failure In a mouse model of diastolic heart failure, injections of …
Published on 5/21/2012
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Amakem N.V., Diepenbeek, Belgium Product: AMA0076 Business: Ophthalmic Indication: Treat primary open-angle glaucoma and ocular hypertension In rabbits, a single topical dose of 0.031-0.625% AMA0076 led to significant …
Published on 5/14/2012
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Eleven Biotherapeutics Inc., Cambridge, Mass. Product: EBI-005 Business: Ophthalmic Indication: Treat dry eye disease In a mouse model of dry eye disease, EBI-005 significantly reduced disease signs as measured by …
Published on 5/14/2012
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Genocea Biosciences Inc., Cambridge, Mass. Product: GEN-003 Business: Infectious Indication: Treat herpes simplex virus (HSV) type 2 infection In mice, GEN-003 induced polyfunctional CD4+ and CD8+ T cell responses as …
Published on 5/14/2012
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Immunocore Ltd., Abingdon, U.K. Product: IMCgp100, ImmTAC-gp100 Business: Cancer Indication: Treat melanoma In a mouse xenograft model of melanoma, once-daily 0.1, 0.04 and 0.01 mg/kg IV ImmTAC-gp100 for 4 days …
Published on 5/14/2012
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Immunocore Ltd., Abingdon, U.K. Product: IMCmage1, ImmTAC-MAGE Business: Cancer Indication: Treat melanoma In a mouse xenograft model of melanoma, 0.01 mg/kg ImmTAC-MAGE given every other day for 10 doses significantly …
Published on 5/14/2012
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Mirna Therapeutics Inc., Austin, Texas Product: miR-34 (formerly miR-Rx34) Business: Cancer Indication: Treat diffuse large B cell lymphoma (DLBCL) In a mouse xenograft model of DLBCL, intratumoral miR-34 reduced tumor …
Published on 5/14/2012
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Promedior Inc., Malvern, Pa. Product: PRM-167 Business: Ophthalmic Indication: Treat age-related macular degeneration (AMD) and diabetic retinopathy In animal models of AMD and diabetic retinopathy, intravitreal …
Published on 5/14/2012
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Senesco Technologies Inc. (NYSE-A:SNT), Bridgewater, N.J. Product: SNS01-T Business: Cancer Indication: Treat multiple myeloma (MM) In a mouse xenograft model of MM, twice-weekly 0.375 mg/kg IV SNS01-T alone and in …
Published on 5/14/2012
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Compugen Ltd. (NASDAQ:CGEN), Tel Aviv, Israel Product: CGEN-15031 Business: Autoimmune Indication: Treat multiple sclerosis (MS) In a mouse model of MS, CGEN-15031 reduced disease symptoms. CGEN-15031 is an Fc fusion …
Published on 5/7/2012
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Compugen Ltd. (NASDAQ:CGEN), Tel Aviv, Israel Product: CGEN-1551 Business: Autoimmune Indication: Treat rheumatoid arthritis (RA) In a mouse model of RA, CGEN-1551 reduced disease symptoms. CGEN-1551 is an Fc fusion …
Published on 5/7/2012
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Presidio Pharmaceuticals Inc., San Francisco, Calif. Product: PPI-383 Business: Infectious Indication: Treat HCV infection In 3-day HCV genotype 1a, 1b, 2a, 3a and 4a replicon assays, oral PPI-383 inhibited all HCV …
Published on 5/7/2012
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Soligenix Inc. (OTCBB:SNGX), Princeton, N.J. Product: RiVax, Ricin Toxin Vaccine Business: Other Indication: Vaccinate against ricin toxin Soligenix said RiVax in combination with ThermoVax vaccine thermostabilization …
Published on 5/7/2012
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Transgene S.A. (Euronext:TNG), Illkirch, France Product: TG1050 Business: Infectious Indication: Prevent HBV infection In mice, subcutaneous TG1050 induced "strong" and specific CD4+ and CD8+ T cell responses as …
Published on 5/7/2012
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Addex Therapeutics (SIX:ADXN), Geneva, Switzerland Product: ADX71441 Business: Genitourinary Indication: Treat overactive bladder (OAB) In female guinea pigs with OAB, animals treated with 1 and 3 mg/kg IV ADX71441 had …
Published on 4/30/2012
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Athersys Inc. (NASDAQ:ATHX), Cleveland, Ohio Product: MultiStem Business: Endocrine/Metabolic Indication: Treat mucopolysaccharidosis I (MPS-I, Hurler's syndrome) In immunodeficient neonatal MPS-I mice, a single …
Published on 4/30/2012
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N-Gene Research Laboratories Inc., New York, N.Y. Product: BGP-15 Business: Musculoskeletal Indication: Treat Duchenne muscular dystrophy (DMD) In mouse models of DMD, once-daily 15 mg/kg oral BGP-15 significantly …
Published on 4/30/2012
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Novartis AG (NYSE:NVS; SIX:NOVN), Basel, Switzerland Product: Kartogenin Business: Autoimmune Indication: Treat osteoarthritis (OA) In collagenase- and surgery-induced mouse models of OA, kartogenin promoted cartilage …
Published on 4/30/2012
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Theralase Technologies Inc. (TSX-V:TLT; OTCBB:TLTFF), Toronto, Ontario Product: Photo Dynamic Compound (PDC) Business: Cancer Indication: Treat colorectal cancer In a mouse model of colorectal cancer, intratumoral …
Published on 4/30/2012