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Chronological Index of : Preclinical Results

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  • Chimerix preclinical data

    Chimerix Inc. (NASDAQ:CMRX), Durham, N.C. Product: Brincidofovir (CMX001) Business: Infectious Indication: Treat Ebola virus infection Chimerix said in vitro data from studies conducted at the CDC and NIH showed that …

    Published on 10/13/2014
  • Aeolus preclinical data

    Aeolus Pharmaceuticals Inc. (OTCQB:AOLS), Mission Viejo, Calif. Product: Manganese porphyrin (AEOL 10150) Business: Other Indication: Treat acute radiation syndrome (ARS) In non-human primates, AEOL 10150 given for 60 …

    Published on 10/6/2014
  • Alnylam preclinical data

    Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: ALN-AGT Business: Genitourinary Indication: Treat preeclampsia In a rat model of preeclampsia, subcutaneous ALN-AGT led to >90% knockdown of …

    Published on 10/6/2014
  • Novan preclinical data

    Novan Inc., Durham, N.C. Product: SB206 Business: Infectious Indication: Treat HPV infection In a rabbit model of HPV infection, topical SB206 led to complete inhibition of papilloma growth. Data were presented at the …

    Published on 9/29/2014
  • arGEN-X preclinical data

    arGEN-X N.V. (Euronext:ARGX), Breda, the Netherlands Product: ARGX-113 Business: Autoimmune Indication: Treat autoimmune diseases In non-human primates, repeat doses of ARGX-113 led to rapid and transient depletion of …

    Published on 9/22/2014
  • Hera Therapeutics preclinical data

    Hera Therapeutics Inc., Del Mar, Calif. Product: HTI-1968 Business: Infectious Indication: Treat HPV infection In cultured human cell models, HTI-1968 blocked the replication of HPV types 11, 16, and 18 cells. Data were…

    Published on 9/22/2014
  • Seek Ltd., ValiRx preclinical data

    Seek Ltd., London, U.K. ValiRx plc (LSE:VAL), London, U.K. Product: VAL401 Business: Cancer Indication: Treat non-small cell lung cancer (NSCLC) In an in vivo model of NSCLC, VAL401 for 6 weeks led to at least a 50% …

    Published on 9/22/2014
  • Soligenix preclinical data

    Soligenix Inc. (OTCBB:SNGX), Princeton, N.J. Product: RiVax, Ricin Toxin Vaccine Business: Other Indication: Vaccinate against ricin toxin In non-human primates, RiVax significantly improved survival against exposure to…

    Published on 9/22/2014
  • Chimerix preclinical data

    Chimerix Inc. (NASDAQ:CMRX), Durham, N.C. Product: Brincidofovir (CMX001) Business: Infectious Indication: Treat adenovirus infection Chimerix reported data at the Interscience Conference on Antimicrobial Agents and …

    Published on 9/15/2014
  • CrystalGenomics preclinical data

    CrystalGenomics Inc. (KOSDAQ:083790), Seongnam, South Korea Product: Polmacoxib (formerly CG100649) Business: Cancer Indication: Treat and prevent colorectal cancer In a premalignant mouse prevention study, polmacoxib …

    Published on 9/15/2014
  • Defyrus, Mapp Biopharmaceutical preclinical data

    Defyrus Inc., Toronto, Ontario Mapp Biopharmaceutical Inc., San Diego, Calif. Product: ZMapp Business: Infectious Indication: Treat Ebola infection In 18 rhesus monkeys, ZMapp initiated 3-5 days post-infection led to a …

    Published on 9/1/2014
  • Immunovaccine preclinical data

    Immunovaccine Inc. (TSX-V:IMV), Halifax, Nova Scotia Product: DepoVax-formulated Ebola vaccine Business: Infectious Indication: Vaccinate against Ebola infection In 4 cynomolgus monkeys, 2 doses of ImmunoVaccines …

    Published on 9/1/2014
  • Addex preclinical data

    Addex Therapeutics Ltd. (SIX:ADXN), Geneva, Switzerland Product: ADX71441 Business: Neurology Indication: Treat nicotine addiction In nicotine-dependent mice, 1, 3 and 10 mg/kg oral ADX71441 administered 60 minutes …

    Published on 8/11/2014
  • Vertex preclinical data

    Vertex Pharmaceuticals Inc. (NASDAQ:VRTX), Boston, Mass. Product: Lumacaftor (VX-809) Business: Pulmonary Indication: Treat cystic fibrosis (CF) Data from a pair of in vitro studies published in Science Translational …

    Published on 7/28/2014
  • ImStem Biotechnology preclinical data

    ImStem Biotechnology Inc., Farmington, Conn. Product: HES-MSCs Business: Autoimmune Indication: Treat multiple sclerosis (MS) In an animal model of MS, human embryonic stem cell-derived mesenchymal stem cells (hES-MSCs)…

    Published on 7/21/2014
  • La Jolla Pharmaceutical preclinical data

    La Jolla Pharmaceutical Co. (NASDAQ:LJPC), San Diego, Calif. Product: LJPC-1010 Business: Hepatic Indication: Treat non-alcoholic steatohepatitis (NASH) In a mouse model of NASH, oral LJPC-1010 significantly reduced non…

    Published on 7/21/2014
  • Blueprint Medicines preclinical data

    Blueprint Medicines, Cambridge, Mass. Product: BLU9931 Business: Cancer Indication: Treat hepatocellular carcinoma (HCC) In mouse xenograft models of fibroblast growth factor 19 (FGF19) amplified and FGF19 …

    Published on 4/21/2014
  • Celldex preclinical data

    Celldex Therapeutics Inc. (NASDAQ:CLDX), Needham, Mass. Product: CDX-014 (formerly CR014-vcMMAE) Business: Cancer Indication: Treat ovarian cancer and renal cell carcinoma (RCC) In mouse xenograft models of ovarian …

    Published on 4/21/2014
  • Genkyotex preclinical data

    Genkyotex S.A., Plan-les-Ouates, Switzerland Product: GKT137831 Business: Pulmonary Indication: Treat idiopathic pulmonary fibrosis (IPF) In aged mice with established pulmonary fibrosis, GKT137831 led to a reversal of …

    Published on 4/21/2014
  • MacroGenics preclinical data

    MacroGenics Inc. (NASDAQ:MGNX), Rockville, Md. Product: MGD007 Business: Cancer Indication: Treat colorectal cancer In a mouse xenograft model of colorectal cancer, doses as low as 4 g/kg IV MGD007 inhibited tumor …

    Published on 4/21/2014
  • NanoAntibiotics preclinical data

    NanoAntibiotics Inc., Surfside, Fla. Product: Efflux pump inhibitor Business: Infectious Indication: Treat bacterial infections In Staphylococcus epidermis bacteria incubated in vitro with tracer dye to monitor the …

    Published on 4/21/2014
  • OncoMed preclinical data

    OncoMed Pharmaceuticals Inc. (NASDAQ:OMED), Redwood City, Calif. Product: OMP-305B83 Business: Cancer Indication: Treat solid tumors OncoMed said OMP-305B83 showed significant in vivo antitumor efficacy in various solid…

    Published on 4/21/2014
  • Onconova Therapeutics preclinical data

    Onconova Therapeutics Inc. (NASDAQ:ONTX), Newton, Pa. Product: ON 1233000 Business: Cancer Indication: Treat mantle cell lymphoma (MCL) and multiple myeloma (MM) In a mouse xenograft model of MCL, once-daily 100 mg/kg …

    Published on 4/21/2014
  • OxiGene preclinical data

    OxiGene Inc. (NASDAQ:OXGN), South San Francisco, Calif. Product: KGP94 Business: Cancer Indication: Treat squamous cell carcinoma of the head and neck (SCCHN) In a mouse model of SCCHN, KGP94 significantly delayed tumor…

    Published on 4/21/2014
  • Regulus preclinical data

    Regulus Therapeutics Inc. (NASDAQ:RGLS), San Diego, Calif. Product: Anti-miR-221 Business: Cancer Indication: Treat hepatocellular cancer (HCC) In a mouse xenograft model of HCC, thrice-weekly subcutaneous 25 mg/kg anti…

    Published on 4/21/2014

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