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Royal DSM N.V. (Euronext:DSM), Heerlen, the Netherlands Product: RHA vaccine Business: Infectious Indication: Vaccinate against H1N1 influenza virus infection In mice, single doses of 1.7, 5 and 15 g recombinant …
Published on 5/13/2013
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Dyax Corp. (NASDAQ:DYAX), Burlington, Mass. Product: DX-2930 Business: Inflammation Indication: Treat and prevent hereditary angioedema (HAE) attacks In rats, subcutaneous DX-2930 reduced carrageenan-induced paw edema …
Published on 3/4/2013
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Roche (SIX:ROG; OTCQX:RHHBY), Basel, Switzerland Product: RG1662 Business: Neurology Indication: Treat cognitive dysfunction associated with Down syndrome In a mouse model of Down syndrome, RO4938581 reversed …
Published on 3/4/2013
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Ventrix Inc., San Diego, Calif. Product: VentriGel Business: Cardiovascular Indication: Prevent congestive heart failure (CHF) following myocardial infarction (MI) In infarcted pigs, percutaneous transendocardial …
Published on 3/4/2013
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Bionomics Ltd. (ASX:BNO; OTCBB:BMICY), Thebarton, Australia Product: BNC101 Business: Cancer Indication: Treat colorectal cancer In a mouse xenograft model of colorectal cancer, BNC101 significantly inhibited growth of …
Published on 2/25/2013
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Phosphagenics Ltd. (ASX:POH; OTCQX:PPGNY), Melbourne, Australia Product: Oxycodone/TPM topical system Business: Neurology Indication: Treat pain In a rat model of pain, topical application of oxycodone/TPM significantly…
Published on 2/25/2013
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Amicus Therapeutics Inc. (NASDAQ:FOLD), Cranbury, N.J. Product: Duvoglustat (AT2220) Business: Endocrine/Metabolic Indication: Treat Pompe's disease In acid alpha glucosidase (GAA) knockout mice, AT2220 co-formulated …
Published on 2/18/2013
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biOasis Technologies Inc. (TSX-V:BTI), Vancouver, B.C. Product: BT2111 Business: Cancer Indication: Treat brain metastasis in patients with HER2+ breast cancer In mice inoculated with a HER2-overespressing human breast …
Published on 2/18/2013
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FluGen Inc., Madison, Wis. Product: REDEE FLU, M2SR Business: Infectious Indication: Vaccinate against H5N1 avian influenza infection In mice, a single dose of intranasal M2SR provided broad-spectrum, long-lasting cross…
Published on 2/18/2013
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International Stem Cell Corp. (OTCBB:ISCO), Carlsbad, Calif. Product: HpSC-derived hepatocytes Business: Hepatic Indication: Treat Crigler-Najjar Syndrome In a rat model of Crigler-Najjar syndrome type 1, implantation …
Published on 2/18/2013
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MiReven Pty. Ltd., Perth, Australia Silence Therapeutics plc (LSE:SLN), London, U.K. Product: MiR-7-5p (microRNA-7-5p) Business: Cancer Indication: Treat metastatic melanoma In vitro, miR-7-5p significantly inhibited …
Published on 2/18/2013
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Tissue Regenix Group plc (LSE:TRX), York, U.K. Product: dCELL Meniscus Business: Musculoskeletal Indication: Soft-tissue knee (meniscus) repair In a sheep model of partial meniscectomy, dCELL Meniscus implanted into the…
Published on 2/18/2013
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BioCryst Pharmaceuticals Inc. (NASDAQ:BCRX), Durham, N.C. Product: BCX5191 Business: Infectious Indication: Treat HCV infection BioCryst said in an SEC filing that it discontinued development of BCX5191 after a non-…
Published on 2/4/2013
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Galectin Therapeutics Inc. (NASDAQ:GALT), Norcross, Ga. Product: GR-MD-02 Business: Renal Indication: Treat diabetic nephropathy In a mouse model of diabetic nephropathy, GR-MD-02 reduced glomerular lesions and the area…
Published on 2/4/2013
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Nimbus Discovery LLC, Cambridge, Mass. Product: ND-630 Business: Endocrine/Metabolic Indication: Treat metabolic syndrome and diabetes Nimbus said ND-630 inhibited hepatic fatty acid synthesis with an ED50 of 0.14 mg/kg…
Published on 2/4/2013
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Cellmid Ltd. (ASX:CDY), Sydney, Australia Product: Anti-midkine antibodies (MK-Abs) Business: Renal Indication: Treat diabetic nephropathy In a mouse model of diabetic nephropathy, 2 of Cellmid's MK-Abs significantly …
Published on 1/28/2013
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Addex Therapeutics Ltd. (SIX:ADXN), Geneva, Switzerland Product: ADX71441 Business: Neurology Indication: Treat Charcot-Marie-Tooth 1A (CMT1A) disease In a rat model of CMT1A, 10 mg/kg oral ADX71441 given every other …
Published on 1/21/2013
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Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: ALN-TMP Business: Hematology Indication: Treat beta-thalassemia In a mouse model of beta-thalassemia, ALN-TMP reduced the severity of anemia as …
Published on 1/21/2013
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Bionomics Ltd. (ASX:BNO; OTCBB:BMICY), Thebarton, Australia Product: BNC375 Business: Neurology Indication: Treat Alzheimer's disease (AD) In mice, Bionomics said BNC375 overcame scopolamine-induced memory deficit with …
Published on 1/21/2013
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Concert Pharmaceuticals Inc., Lexington, Mass. Product: CTP-221 Business: Cancer Indication: Treat multiple myeloma (MM) In in vitro efficacy assays, CTP-221 produced a 2.7-fold increase in IL-2 induction in anti-CD3 …
Published on 1/21/2013
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La Jolla Pharmaceutical Co. (Pink:LJPC), San Diego, Calif. Product: GCS-100 Business: Hepatic Indication: Treat chronic liver disease In a mouse model of non-alcoholic steatohepatitis-hepatocellular carcinoma (NASH-HCC…
Published on 1/21/2013
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Proteome Sciences plc (LSE:PRM), Cobham, U.K. Product: PS110 Business: Neurology Indication: Treat Alzheimer's disease (AD) In a mouse model of AD, PS110 improved cognitive function as assessed by the Morris Water Maze …
Published on 1/21/2013
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Proteome Sciences plc (LSE:PRM), Cobham, U.K. Product: PS278-05 Business: Neurology Indication: Treat Alzheimer's disease (AD) In a mouse model of AD, PS278-05 improved cognitive function as assessed by the Morris Water…
Published on 1/21/2013
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Revalesio Corp., Tacoma, Wash. Product: RNS60 Business: Autoimmune Indication: Treat multiple sclerosis (MS) In a mouse model of MS, RNS60 halted disease progression and prevented inflammation in the brain and spinal …
Published on 1/21/2013
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Rhizen Pharmaceuticals S.A., La Chaux-de-Fonds, Switzerland TG Therapeutics Inc. (OTCBB:TGTX), New York, N.Y. Product: TGR-1202 (formerly RP5264) Business: Cancer Indication: Treat B cell lymphoma In antigen recognition…
Published on 1/21/2013