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Chronological Index of : Clinical Status

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  • 5B1 antibody: Phase I start

    MabVax Therapeutics Holdings Inc. (OTCQB:MBVX), San Diego, Calif. Product: 5B1 antibody, HuMab-5B1 (MVT-5873) Business: Cancer Molecular target: Undisclosed Description: Human IgG1 antibody Indication: Treat metastatic …

    Published on 2/1/2016
  • ADU-741: Phase I started

    Aduro Biotech Inc. (NASDAQ:ADRO), Berkeley, Calif. Johnson & Johnson (NYSE:JNJ), New Brunswick, N.J. Product: ADU-741, JNJ-64041809 Business: Cancer Molecular target: NA Description: Live-attenuated, double-deleted …

    Published on 2/1/2016
  • AK001: Phase I ongoing

    Allakos Inc., San Carlos, Calif. Product: AK001 Business: Inflammation Molecular target: Undisclosed Description: Antibody targeting an inhibitory receptor on mast cells and eosinophils Indication: Treat atopic disease …

    Published on 2/1/2016
  • Anetumab ravtansine: Phase II started

    MorphoSys AG (Xetra:MOR), Martinsried, Germany Bayer AG (Xetra:BAYN), Leverkusen, Germany Product: Anetumab ravtansine (BAY 94-9343) Business: Cancer Molecular target: Mesothelin Description: Human HuCAL-based antibody-…

    Published on 2/1/2016
  • ARC-520: Phase IIb started

    Arrowhead Research Corp. (NASDAQ:ARWR), Pasadena, Calif. Product: ARC-520 Business: Infectious Molecular target: NA Description: Short interfering RNAs targeting 2 regions of the HBV genome conjugated to N-…

    Published on 2/1/2016
  • BeiGene-290: Phase I started

    BeiGene Ltd., Beijing, China Merck KGaA (Xetra:MRK), Darmstadt, Germany Product: BeiGene-290, BGB-290 Business: Cancer Molecular target: Poly(ADP-ribose) polymerase-1 (PARP-1); Poly(ADP-ribose) polymerase-2 (PARP-2) …

    Published on 2/1/2016
  • BGB-A317: Phase I started

    BeiGene Ltd., Beijing, China Product: BGB-A317 Business: Cancer Molecular target: Programmed cell death 1 (PD-1) (PDCD1) (CD279) Description: Humanized anti-PD-1 mAb Indication: Treat advanced solid tumors Endpoint: …

    Published on 2/1/2016
  • BIA 10-2474: Phase I halted

    Bial-Portela & Ca. S.A., S. Mamede do Coronado, Portugal Product: BIA 10-2474 Business: Neurology Molecular target: Fatty acid amide hydrolase (FAAH) Description: Fatty acid amide hydrolase (FAAH) inhibitor Indication: …

    Published on 2/1/2016
  • Bryostatin-1: Phase IIb started

    Neurotrope Inc. (OTCQB:NTRP), Newark, N.J. Product: Bryostatin-1 Business: Neurology Molecular target: Protein kinase C (PKC) epsilon (PKCE) Description: Protein kinase C (PKC) epsilon (PKCE) activator Indication: Treat…

    Published on 2/1/2016
  • CBLB612: Phase II started

    Cleveland BioLabs Inc. (NASDAQ:CBLI), Buffalo, N.Y. Product: CBLB612 Business: Hematology Molecular target: Toll-like receptor 2 (TLR2); Toll-like receptor 6 (TLR6) Description: Synthetic lipopeptide derived from …

    Published on 2/1/2016
  • CGF166: Phase I/II suspended enrollment

    GenVec Inc. (NASDAQ:GNVC), Gaithersburg, Md. Novartis AG (NYSE:NVS; SIX:NOVN), Basel, Switzerland Product: CGF166 Business: Other Molecular target: Atonal homolog 1 (ATOH1) (HATH1) Description: Recombinant adenovirus 5…

    Published on 2/1/2016
  • DTX101: Phase I/II started

    RegenxBio Inc. (NASDAQ:RGNX), Washington, D.C. Dimension Therapeutics Inc. (NASDAQ:DMTX), Cambridge, Mass. Product: DTX101 Business: Hematology Molecular target: Factor IX Description: Recombinant adeno-associated virus…

    Published on 2/1/2016
  • eFT508: Phase I/II started

    Effector Therapeutics Inc., San Diego, Calif. Product: eFT508 Business: Cancer Molecular target: MAP kinase interacting serine-threonine kinase 1 (MKNK1) (MNK1); MAP kinase interacting serine-threonine kinase 2 (MKNK2)…

    Published on 2/1/2016
  • EGP-437: Phase III started

    EyeGate Pharmaceuticals Inc. (NASDAQ:EYEG), Waltham, Mass. Valeant Pharmaceuticals International Inc. (TSX:VRX; NYSE:VRX), Laval, Quebec Product: EGP-437 Business: Ophthalmic Molecular target: NA Description: …

    Published on 2/1/2016
  • EV06: Completed Phase I/II enrollment

    Encore Vision Inc., Fort Worth, Texas Product: EV06 Business: Ophthalmic Molecular target: NA Description: 1.5% lipoic acid choline ester, which breaks down into lipoic acid and choline Indication: Treat presbyopia …

    Published on 2/1/2016
  • FG-3019: Phase II started

    FibroGen Inc. (NASDAQ:FGEN), San Francisco, Calif. Product: FG-3019 Business: Musculoskeletal Molecular target: Connective tissue growth factor (CTGF) Description: Human mAb against connective tissue growth factor (CTGF…

    Published on 2/1/2016
  • GLPG2222: Phase I started

    Galapagos N.V. (Euronext:GLPG; NASDAQ:GLPG), Mechelen, Belgium AbbVie Inc. (NYSE:ABBV), Chicago, Ill. Product: GLPG2222 Business: Pulmonary Molecular target: Cystic fibrosis transmembrane conductance regulator (CFTR) …

    Published on 2/1/2016
  • Graspa: Phase IIb ongoing

    Erytech Pharma S.A. (Euronext:ERYP), Lyon, France Product: Graspa, ERY-ASP (ERY001) Business: Cancer Molecular target: NA Description: L-asparaginase encapsulated in red blood cells Indication: Treat acute myelogenous …

    Published on 2/1/2016
  • IMP321: Phase I started

    Prima BioMed Ltd. (ASX:PRR; NASDAQ:PBMD), Sydney, Australia Product: IMP321 (formerly ImmuFact IMP321) Business: Cancer Molecular target: Major histocompatibility complex class II (MHCII); Lymphocyte-activation gene 3 (…

    Published on 2/1/2016
  • JNJ-42165279: Phase II hold

    Johnson & Johnson (NYSE:JNJ), New Brunswick, N.J. Product: JNJ-42165279 Business: Neurology Molecular target: Fatty acid amide hydrolase (FAAH) Description: Fatty acid amide hydrolase (FAAH) inhibitor Indication: Treat …

    Published on 2/1/2016
  • JNJ-42165279: Phase II hold

    Johnson & Johnson (NYSE:JNJ), New Brunswick, N.J. Product: JNJ-42165279 Business: Neurology Molecular target: Fatty acid amide hydrolase (FAAH) Description: Fatty acid amide hydrolase (FAAH) inhibitor Indication: Treat …

    Published on 2/1/2016
  • Laquinimod: Phase II amended

    Active Biotech AB (SSE:ACTI), Lund, Sweden Teva Pharmaceutical Industries Ltd. (NYSE:TEVA), Petah Tikva, Israel Product: Laquinimod (SAIK-MS) Business: Neurology Molecular target: S100 calcium binding protein A9 (S100A9…

    Published on 2/1/2016
  • Luminate: Completed Phase IIb enrollment

    Allegro Ophthalmics LLC, San Juan Capistrano, Calif. Hanmi Pharmaceutical Co. Ltd. (KOSDAQ:128940), Seoul, South Korea Senju Pharmaceutical Co. Ltd., Osaka, Japan Product: Luminate (ALG-1001) Business: Ophthalmic …

    Published on 2/1/2016
  • ONC201: Phase II started

    Oncoceutics Inc., Hummelstown, Pa. Product: ONC201 Business: Cancer Molecular target: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL); Tumor necrosis factor (TNF) receptor superfamily member 10b (…

    Published on 2/1/2016
  • Pidilizumab: FDA hold

    CureTech Ltd., Yavne, Israel Medivation Inc. (NASDAQ:MDVN), San Francisco, Calif. Product: Pidilizumab (CT-011, MDV9300) Business: Cancer Molecular target: NA Description: Humanized mAb against an undisclosed target …

    Published on 2/1/2016

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