Table 1. NIH Blueprint Neurotherapeutics Network awards.

Indication

Project description

Institution

Amyotrophic lateral sclerosis (ALS)

Small molecule modulators of the glutamate transporter

Brigham and Women's Hospital

Alzheimer's disease (AD)

Optimization of soluble g-secretase modulators

University of California, San Diego

Depression

Optimization of a new opioid receptor d1 (OPRD1; DOR) biased agonist

Trevena Inc.

Hearing loss

Drug discovery for the prevention of hearing loss

University of Washington

Age-related macular degeneration (AMD)

Small molecule therapeutics for dry AMD

Columbia University

Optic neuropathy

Triazine compounds for optic nerve regeneration

University of Miami

Stroke

Prostaglandin E2 receptor EP2 subtype (prostanoid EP2 receptor; PTGER2) modulators for brain hemorrhage

Emory University