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AIMM Therapeutics has devised a way to harness the high diversity and efficacy of human mAbs for therapeutic applications. There are a number of competing technologies in the space, and the optimal choice of platform is…
Published on 1/14/2010
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Duke researchers have developed an in vivo selection process to isolate RNA aptamers that bind to tumor-associated proteins. The approach could simplify the generation of molecular probes and aid both the development of…
Published on 1/7/2010
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Tools: A call to arms Table 1. IgG4 antibodies. There are a host of antibodies in development that have IgG4 backbones. Two have already reached the market and no fewer than five are in Phase II testing. Company …
Published on 12/17/2009
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Although a paper published by Genmab researchers proposed a mechanism by which IgG4 antibodies might elicit side effects, PanGenetics has a different take. PanGenetics thinks that antibody backbones are a red herring …
Published on 12/17/2009
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University of Washington scientists have quickly used their recently published exome-sequencing technique to identify the causal gene for a rare Mendelian disorder called Miller syndrome. The group views this as a …
Published on 12/10/2009
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University College London and The Netherlands Cancer Institute researchers have engineered Tregs to be antigen specific and have used them to suppress the arthritis-related immune response. The approach could lead to …
Published on 12/3/2009
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University of Toronto researchers have combined ex vivo IL-10 gene therapy with an organ preservation system from Vitrolife AB to repair damage in donor lungs and make them suitable for transplant. The approach could …
Published on 11/19/2009
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Apogee Technology and academic collaborators have shown that intradermal delivery of an antigen and the polymer PCPP-a known adjuvant for intramuscular vaccines-elicited stronger immune responses than the same …
Published on 11/12/2009
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Scripps researchers have developed a small molecule approach that provides more than a 200-fold boost in the generation of induced pluripotent stem cells from human fibroblasts while cutting the generation time in half.…
Published on 10/29/2009
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European researchers have developed a microarray technology that, without requiring any up-front genomic information, can aid in the identification and exploration of biosynthetic pathways in microorganisms that produce…
Published on 10/22/2009
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Stanford researchers show that localized application of ultrasound can be used to amplify the release of cancer biomarkers into the blood. The group thinks ultrasound-mediated biomarker release could improve disease …
Published on 10/22/2009
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North Carolina researchers have designed splicing factors that can selectively promote or inhibit the expression of specific isoforms of a target gene to treat cancer. The approach has immediate application for research…
Published on 10/15/2009
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Duke researchers have developed a universal strategy for reversing the activity of oligonucleotide aptamers. These control agents could bolster the safety of aptamer therapeutics, make them more economically attractive …
Published on 10/15/2009
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M.D. Anderson researchers have developed a modified idiotype-based vaccination strategy to treat lymphoma and are already planning a clinical trial based on challenge studies in mice. But other researchers question …
Published on 10/8/2009
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Tools: Silent but deadly delivery Figure 1. The dual effect of a CpG-siRNA conjugate. Researchers showed that fusing a CpG oligonucleotide with a small interfering RNA molecule targeting signal transducer and …
Published on 10/1/2009
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U.S. researchers have developed a method using CpG oligonucleotides to deliver siRNA to immune cells for treating cancer. The technology could be a platform for other siRNA-based therapeutics, although the safety of the…
Published on 10/1/2009
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University of Washington researchers have developed a targeted sequencing approach using the exome to identify rare genetic variants underlying inherited disorders. The approach could lower the cost of discovery, but …
Published on 9/17/2009
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Researchers at Duke University have developed an alternative to pegylation that could be useful for synthesizing therapeutic protein-polymer conjugates with favorable pharmacokinetic profiles, good retention of protein …
Published on 9/10/2009
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Tools: Next Steps for Pluripotent iPS cells Figure 1: Testing for Pluripotency Figure 1. Testing for pluripotency. Tetraploid complementation is the most stringent test of pluripotency. [a] Fibroblast cells are …
Published on 9/3/2009
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Now that three teams in California and China have succeeded in inducing truly pluripotent iPS cells, the next hurdles include learning how to produce and select iPS cells with the best developmental potential and …
Published on 9/3/2009
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Tools: In arm's way Figure 1. Toxicity and IgG4 antibody fragment exchange. The exchange of Fab arms between therapeutic and endogenous IgG4 antibodies can result in a mAb with specificity for both its intended …
Published on 8/20/2009
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A team led by Genmab has shown that IgG4-based therapeutic antibodies can exchange Fab arms with endogenous IgG4 antibodies. Unwanted biological consequences could potentially include the cases of progressive multifocal…
Published on 8/20/2009
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Tools: Targeting toxic RNA Figure 1. Effect of RNA expansion on disease pathology and therapeutic intervention. Molecules targeting RNA repeats could be useful for treating diseases in which expansion of these …
Published on 8/6/2009
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University of Rochester scientists have used an antisense molecule to reverse muscular defects in a mouse model of the most common form of adult muscular dystrophy. The approach may be applicable to other diseases that …
Published on 8/6/2009
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Transdermal transgene control Figure 1. Transdermal control of protein production in a subcutaneous implant. Researchers at the Swiss Federal Institute of Technology Zurich (ETHZ) generated mammalian cells containing…
Published on 7/30/2009