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U.S. researchers have designed a mouse model of blast-induced brain injury and shown that the animal develops chronic traumatic encephalopathy, a condition associated with concussive injuries in athletes. They plan to …
Published on 6/7/2012
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A group of Australian researchers and an FDA-led team have independently identified a mechanism behind HLA allele-mediated autoimmune reactions to certain drugs. The findings could expand the use of HLA genotyping in …
Published on 6/7/2012
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UCSF and UT Southwestern researchers have shown that direct reprogramming of cardiac fibroblasts into cardiomyocyte-like cells is feasible in vivo and could promote the recovery of cardiac function after myocardial …
Published on 5/31/2012
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Two teams have generated extensive data on sequence variation in genes that encode drug targets. The next step is figuring out if-and how-the variants influence drug response and disease susceptibility.
Published on 5/31/2012
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GSK and Yale researchers have announced a collaboration to develop a platform that selectively tags disease-associated proteins with an E3 ubiquitin ligase ligand, thus targeting them to a cell's protein degradation …
Published on 5/17/2012
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U.S. researchers have developed a dendrimer-based therapy that reduced brain inflammation and improved the motor function of newborn rabbits with cerebral palsy. The team now needs to determine the therapy's treatment …
Published on 5/10/2012
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An international team has engineered enzymes capable of replicating nucleic acid polymers that are made of unnatural nucleotides. Despite general media reports, the technology is not likely to lead to artificial life …
Published on 5/3/2012
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Massachusetts researchers have developed an RNA-based method for the rapid detection of pathogens in clinical samples. The team is now designing an integrated diagnostic platform that contains a comprehensive set of …
Published on 4/19/2012
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UCSF researchers have created a class of reversible, covalent small molecule kinase inhibitors that could be more selective and safer than previous kinase inhibitors. Principia Biopharma has exclusively licensed the …
Published on 4/12/2012
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Researchers from UCSD and the Gladstone Institute of Cardiovascular Disease have developed a system for genomic-based drug screening that combines mRNA profiling and an automated, high throughput sequencing platform. …
Published on 4/5/2012
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Xpress sequencing for express screening Figure 1. High throughput sequencing for drug discovery. As reported in Li et al., a high throughput sequencing platform could aid the discovery of compounds that reverse gene …
Published on 4/5/2012
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NoNO has become the first company to show that macaque models could bridge the rodent-human gap to potentially derisk clinical testing of new stroke therapies. The company reported that its neuroprotective peptide NA-1 …
Published on 3/22/2012
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Researchers at Harvard University have designed drug delivery vehicles dubbed DNA nanorobots that enable the conditional delivery of therapeutic payloads based on the presence of combinations of markers on target cells.…
Published on 3/1/2012
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Harvard Medical School researchers have shown that noninvasive detection of a key metabolite in the brain can diagnose IDH1-mutant tumors. Agios plans to use the method for the preclinical development of its glioma …
Published on 2/2/2012
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Max Planck cell biologists are challenging the research community to abandon the HeLa cell line in favor of stem cell lines. Although the latter may provide better in vitro disease models, technical and economic …
Published on 1/26/2012
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Brazilian and U.S. researchers have engineered a prototype cancer immunotherapy consisting of an attenuated strain of Trypanosoma cruzi expressing a cancer antigen that stimulates a potent response in mice. The team is …
Published on 1/12/2012
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NCI and University of Tokyo researchers have developed a fluorescent probe that can be sprayed onto tissue during surgery to detect small metastases. The researchers plan to validate the method in fresh surgical tissue …
Published on 1/5/2012
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A Stanford team has developed a computational pathology system called C-Path that provides more accurate prognostic scores of breast cancer tissue than classical pathology. The next steps will be modifying the method to…
Published on 12/15/2011
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Dana-Farber researchers have developed an in vitro assay that predicts patient response to chemotherapy by directly measuring whether a cell is prone to apoptosis. Eutropics has exclusively licensed the assay and is …
Published on 12/15/2011
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A Memorial Sloan-Kettering team has honed a protocol for producing large quantities of human dopaminergic neurons that could be grafted into patients with PD or used as a screening platform for the disease. Scaling up …
Published on 12/1/2011
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Putting pluripotent pieces together Figure 1. From fibroblast to functional hepatocyte. Fibroblasts from individuals with mutant a1-antitrypsin (AAT; A1AT; SERPINA1) are transformed into induced pluripotent stem (iPS…
Published on 11/3/2011
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An international team has developed a method for genetically altering induced pluripotent stem cells that could be useful for treating inherited diseases. The team now plans to scale up the method but will need to show …
Published on 11/3/2011
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U.K. researchers are designing a trial at the University of Cambridge to verify the validity and utility of a prognostic gene expression signature in CD8+ T cells to guide treatment decisions for inflammatory bowel …
Published on 10/27/2011
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U.S. researchers have engineered mice that model the mechanisms of three relatively common genetic causes of autism spectrum disorder, making it possible to undertake phenotypic screening for therapeutics. Behavioral …
Published on 10/20/2011
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U.S. researchers have compared mouse proteomes to identify plasma protein signatures that could be mined for biomarkers to aid the detection of lung cancer. The signatures may lead to a noninvasive follow-up test to …
Published on 10/6/2011