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  • Revisiting adrenomedullin in preeclampsia

    A North Carolina team has shown that fetal deficiency in adrenomedullin resulted in mouse placental abnormalities similar to those found in preeclampsia. The results point to adrenomedullin as a potential marker for the…

    Published on 5/23/2013
  • CRISPR model building

    Boston researchers have used the CRISPR-Cas9 genome modification platform to simultaneously engineer mutations into multiple genes in mice. The results from the rapid, one-step process provide the best evidence to date …

    Published on 5/16/2013
  • Myelination gets direct

    Separate groups at Case Western and Stanford have developed approaches to directly reprogram rodent fibroblasts into oligodendrocyte progenitor cells. Although the method could be a safe and fast way to supply cells for…

    Published on 5/16/2013
  • Figure 1: Isolating CTCs

    CTCs gain character(ization) Figure 1. Isolating CTCs. The circulating tumor cell (CTC)-iChip uses magnetic beads to label cells in whole blood. The blood sample is loaded onto the chip, on which lateral displacement…

    Published on 5/2/2013
  • CTCs gain character(ization)

    Massachusetts General Hospital researchers have developed a microfluidic platform able to identify circulating tumor cells that lack EpCAM. Johnson & Johnson has rights to the technology under a 2011 deal and is funding…

    Published on 5/2/2013
  • Regenerating the kidney

    Researchers at Harvard Medical School and Massachusetts General Hospital have shown that their platform for creating transplantable bioengineered organs from decellularized matrices can be used to create a functional …

    Published on 4/25/2013
  • Crystalline sponges to aid X-ray analysis

    University of Tokyo researchers have used porous metal complexes dubbed crystalline sponges to enable X-ray crystallography of natural small molecules that do not readily crystallize. The group is forming a company to …

    Published on 4/18/2013
  • Expanding the aptamer alphabet

    A RIKEN and TagCyx team has used unnatural nucleotides to generate DNA aptamers with 100-fold higher binding affinities than aptamers containing only natural nucleotides. The group plans to develop the aptamers for …

    Published on 4/18/2013
  • Figure 1: Automated SAR studies

    The mechanical chemist Figure 1. Automated SAR studies. Desai et al. at Cyclofluidic Ltd. have demonstrated the automated optimization of kinase inhibitors in an integrated synthetic and analytic chemistry platform.…

    Published on 4/4/2013
  • The mechanical chemist

    Cyclofluidic has shown that its automated microfluidic lead optimization platform can identify new BCR-ABL tyrosine kinase inhibitors. The company's next step is showing that automated hit-to-lead optimization will work…

    Published on 4/4/2013
  • Figure 1: Improving tumor vaccine formulation

    Tools: Awakening tumor immunity Figure 1. Improving tumor vaccine formulation. Hailemichael et al. have shown that a widely used adjuvant leads to T cell inactivity that impairs the efficacy of cancer vaccines and …

    Published on 3/28/2013
  • Awakening tumor immunity

    MD Anderson researchers have figured out why many cancer vaccines fail to elicit a robust T cell response -- the cells loiter near the vaccination site instead of migrating to the tumor. The solution is switching the …

    Published on 3/28/2013
  • Nanoparticles for lupus

    A Yale group has designed a nanoparticle that selectively delivered an immunosuppressant to immune cells and improved survival in mouse models of lupus. The platform has been exclusively licensed to Immunova, which is …

    Published on 3/21/2013
  • VentriGel goes into pigs

    Researchers at UCSD and Ventrix have developed a catheter-compatible hydrogel that restored cardiac function in a pig model with myocardial infarction. Ventrix is now scaling up manufacture of the hydrogel, called …

    Published on 3/14/2013
  • Cardiomyocytes acting like adults

    A Sanford-Burnham Medical Research Institute team has developed a model for arrhythmogenic right ventricular dysplasia/cardiomyopathy that replicates the phenotype of the disease. The key innovation was getting the iPS …

    Published on 2/28/2013
  • Small molecules vs teratomas

    Researchers at The Hebrew University of Jerusalem and Roche have identified small molecules that prevented human pluripotent stem cells from forming teratomas in mice following transplantation. The molecules could be …

    Published on 2/21/2013
  • Tethered capsule endomicroscopy

    Massachusetts General Hospital researchers have created a tethered, capsule-size endoscope that can generate 3D microstructural images of the upper GI tract. The team used the device to image Barrett's esophagus in …

    Published on 2/14/2013
  • Figure 1: Adoptive T cell-based immunotherapy strategies

    Rejuvenating T cells Figure 1. Adoptive T cell-based immunotherapy strategies. Two teams reprogrammed antigen-specific CD8+ T cells (orange cells) using Yamanaka factors and SV40 large T antigen to produce induced …

    Published on 2/7/2013
  • Rejuvenating T cells

    Two Japanese teams have used iPS cells to regenerate antigen-specific T cells in patients whose immune systems have been depleted. Megakaryon is developing the technology of one group to produce iPS cell-derived human T…

    Published on 2/7/2013
  • Sequencing single B cells

    University of Texas researchers have developed a high throughput method for sequencing individual B cell immunoglobulin receptors that keeps the link between their paired heavy and light variable chains intact. The next…

    Published on 2/7/2013
  • Sarepta's hemorrhagic mouse

    A Sarepta team has developed a mouse model of arenavirus infection that recapitulates key symptoms of the disease including hemorrhagic fever and multiorgan failure. The researchers are now interested in using the mice …

    Published on 1/24/2013
  • Scaling up iPS cells

    A Memorial Sloan-Kettering team has conducted one of the first large-scale screens of a small molecule library in neuronal cells obtained by differentiating patient-derived iPS cells. Separately, a partnership led by …

    Published on 1/10/2013
  • Box 1: TRPV4 inhibition

    Pulmonary edema on a chip Box 1. TRPV4 inhibition. While the Boston team tested GlaxoSmithKline plc's transient receptor potential vanilloid 4 (TRPV4; VRL2) inhibitor GSK2193874 in a lung-on-a chip model, the pharma…

    Published on 12/13/2012
  • Pulmonary edema on a chip

    Researchers at the Wyss Institute have described an organ-on-a-chip microfluidic model of pulmonary edema that could be better than culture models at predicting whether therapeutics will translate to humans. The team …

    Published on 12/13/2012
  • Micromanaging tolerance

    Researchers at Northwestern University and the Myelin Repair Foundation have simplified an autologous cell-based strategy for promoting antigen-specific tolerance by replacing splenic leukocytes with synthetic …

    Published on 12/6/2012

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