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French researchers have engineered food-grade lactic acid bacteria that secrete the protease inhibitor elafin, a promising therapeutic for intestinal inflammation. Oral delivery of the engineered bacteria reduced …
Published on 11/8/2012
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A Harvard Medical School and Tsinghua University team has developed a technology, dubbed MuSIC, that identifies synergistic drug pairs. The group showed proof of concept by finding new combinations of therapeutics for …
Published on 11/8/2012
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A Duke University team has figured out how to grow large numbers of regulatory B cells. The researchers used the bounty of cells to tone down autoimmunity in a mouse model of MS.
Published on 10/25/2012
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University of Pittsburgh School of Medicine researchers have shown that transplanting cells into mouse lymph nodes leads to engraftment and generation of ectopic tissue mass that could replace the function of failing …
Published on 10/18/2012
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U.S. researchers have developed a postage stamp-sized diagnostic for hepatotoxicity and have shown that it measured liver enzyme levels in human blood serum. Diagnostics for All has exclusively licensed the device and …
Published on 10/4/2012
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Memorial Sloan-Kettering Cancer Center researchers have developed a transferrin-based PET imaging agent that could help diagnose prostate cancer with greater sensitivity than 18F-labeled fluorodeoxyglucose. It also can …
Published on 10/4/2012
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U.S. researchers have developed the first mouse model that recapitulates the human stages of the malarial parasite Plasmodium falciparum life cycle. The academics plan to make additional modifications to the mice to …
Published on 9/27/2012
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University of Georgia researchers have developed a polymeric nanoparticle technology that can selectively deliver small molecules to the mitochondria of cultured cells. The researchers are evaluating the nanoparticles …
Published on 9/27/2012
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Tools: Strategic synergy Figure 1. Nkg2d ligands contribute to the synergy of radiotherapy and anti-CTLA-4 mAbs. In mice with poorly immunogenic murine carcinoma cells treated with an anti-CTLA-4 (CD152) antibody, …
Published on 9/20/2012
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NYU researchers have shown that the induction of NKG2D ligands contributes to the synergy of radiotherapy with an anti-CTLA-4 mAb. The findings could be used to identify patients most likely to respond to anti-CTLA-4 …
Published on 9/20/2012
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Tools: Cracking ENCODE Figure 1. Rethinking disease markers. Maurano et al. have uncovered evidence from genomewide association studies that the majority of noncoding DNA regions implicated in disease may exert their…
Published on 9/13/2012
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ENCODE, a massive effort to characterize the functional elements of the human genome, went public with its findings last week. For industry, the data are likely to spark a re-examination of genomewide association study …
Published on 9/13/2012
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Researchers at Stanford University and Texas A&M University have synthesized highly sensitive class A Beta-lactamase-specific fluorogenic probes that could enable the development of a fast and simple point-of-care …
Published on 9/13/2012
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National Cheng Kung University researchers have developed an injectable self-assembling peptide nanofiber scaffold that enables sustained VEGF delivery and establishes a microenvironment that augments arteriogenesis and…
Published on 9/6/2012
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General media coverage of deCode's recent findings about the potential relationship between paternal age, single mutation rates and incidence of neuropsychiatric diseases has masked the more fundamental insights gained …
Published on 8/30/2012
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A UCSD team has developed a genetic method to prevent embryonic stem cell therapies from forming cancerous teratomas following transplantation. The method was safe in mice, although questions remain about whether the …
Published on 8/30/2012
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U.K. and Massachusetts researchers have built a screening platform to find biofilm-resistant polymers that can be used to protect implantable devices from biofilms.
Published on 8/23/2012
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Two independent research teams have used cell culture methods to show that excessive HGF/SF activity drives resistance to BRAF inhibitors in melanoma. The findings could provide a rationale for combining HGF/SF or MET …
Published on 8/16/2012
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UCSF and Mount Sinai researchers have used whole-organism screening in a Drosophila cancer model to identify and optimize a multitargeted kinase inhibitor with activity in a mouse model of medullary thyroid carcinoma. …
Published on 8/2/2012
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UCSF, SeaChange and Novartis have developed a computational approach for large-scale, automated prediction of binding interactions between small molecules and targets that have been associated with adverse drug …
Published on 7/19/2012
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A Johns Hopkins team has shown that antiviral-loaded, mucus-penetrating particles can be used for vaginal delivery to help prevent herpes simplex virus infection. The team thinks the particles have potential to deliver …
Published on 7/12/2012
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Fred Hutchinson researchers have developed a high throughput sequencing platform to detect minimal residual disease in patients with T cell acute lymphoblastic leukemia. The team has spun out Adaptive Biotechnologies …
Published on 6/14/2012
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An Oregon Health & Science University and Najít team has shown that hydrogen peroxide could be a better way to inactivate viral vaccines than conventional methods. Najít hopes to start a Phase I trial of an inactivated …
Published on 6/14/2012
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Blasted Brain Figure 1. Brain on the battlefield. Research published in Science Translational Medicine by scientists at the Boston University School of Medicine has shown that a single concussive air blast is …
Published on 6/7/2012
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HLA in sequence Box 1. Human leukocyte antigen genotyping. A Stanford University team has developed a new human leukocyte antigen (HLA) sequencing method that could be more cost effective and accurate than existing …
Published on 6/7/2012