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  • Scleroderma models: skin in the game

    North American researchers have mouse data showing that mutated fibrillin 1 recapitulates skin fibrosis and other symptoms seen in systemic scleroderma. The group also found downstream proteins whose expression was …

    Published on 11/14/2013
  • Phenotypic screening on target

    A Stanford-UCSF team has fished out a new class of NAMPT inhibitor using a phenotypic screen coupled with an shRNA-based target identification system. The method could have broad applicability in matching hits to …

    Published on 11/7/2013
  • Seeing CCR5

    A crystal structure of human CCR5 bound to the marketed HIV drug Selzentry reveals a unique binding site for the compound. The structural snapshot in combination with molecular modeling could guide future drug discovery…

    Published on 10/10/2013
  • Trapping human genes

    The Research Center for Molecular Medicine of the Austrian Academy of Sciences and Haplogen have generated a library of haploid knockout human cells that allows for the systematic investigation of gene function in vitro…

    Published on 9/26/2013
  • Figure 1: CAR-expressing T cell production to develop immunotherapeutics

    Tools: Supersizing adoptive T cell therapies Figure 1. CAR-expressing T cell production to develop immunotherapeutics. (I) Themeli et al. transduced a healthy volunteer's T cells with two retroviral vectors encoding …

    Published on 9/19/2013
  • Brain in a dish

    Austrian researchers grabbed headlines last month when they coaxed cultured human iPS cells into forming brain tissue, but in actuality the approach does not offer applications beyond studying very early brain …

    Published on 9/19/2013
  • Supersizing adoptive T cell therapies

    Studies of CAR-based T cell therapies are limited by the lack of a suitable supply of human T lymphocytes. Memorial Sloan-Kettering Cancer Center researchers have used patient-derived iPS cells for large-scale …

    Published on 9/19/2013
  • Crisper results for CRISPR

    CRISPR-based genome editing is touted for its simplicity and efficiency over other platforms, but recently published data raise concerns about its specificity. Broad Institute researchers have generated an updated …

    Published on 9/12/2013
  • Molecular biocontainment for the flu

    A U.S. team has engineered a flu virus that is transmissible among ferrets but not humans. The containment strategy provides a safeguard in case of accidental or intentional misuse of research viruses, although how well…

    Published on 9/12/2013
  • Table 1: Behavior DISCrimination

    DISCerning schizophrenia in mice Table 1. Behavior DISCrimination. Experiments are based on fixed-period sessions in which animals are placed in an enclosed chamber, and the number of times they produce a response is…

    Published on 8/29/2013
  • DISCerning schizophrenia in mice

    A team at The Johns Hopkins University has created a transgenic mouse model of prefrontal dysfunction involving disrupted networks of neurons that cause behavioral changes similar to those seen in patients with …

    Published on 8/29/2013
  • Chromosome shutdown

    A new technique to shut down chromosome 21 will reshape how Down syndrome is modeled and, in the longer term, could point to new disease targets or a strategy to remove the extra chromosome in patient cells.

    Published on 8/15/2013
  • A new wave of arrhythmia assays

    Although the race is on to select and validate new preclinical assays that the FDA will accept as replacements for current tests to predict a molecule's arrhythmia potential, the field continues to make even newer …

    Published on 8/8/2013
  • The liver's new bud

    Japanese researchers have produced vascularized human liver tissue that displays promising metabolic and regenerative capacity in mice. The group now aims to scale up the procedure to generate bigger tissue segments and…

    Published on 8/1/2013
  • Universal appeal for CARs

    MD Anderson and Sangamo are overcoming the need for autologous cells in CAR-expressing T cell-based immunotherapies. The group has used gene-modifying tools to mask donor-derived T cells from immune surveillance …

    Published on 7/25/2013
  • Cancer genome statistics lesson

    The Broad Institute has upgraded its original algorithm for cancer genome analysis to account for gene-specific differences in mutation rates. Application of the improved algorithm could help identify previously …

    Published on 7/18/2013
  • Attenuating attrition

    High drug attrition rates from poor clinical safety have spawned numerous in silico optimization algorithms for molecule design, but none has emerged as a true game changer. AstraZeneca and Roche are pooling their data …

    Published on 7/11/2013
  • Bilirubin glow

    RIKEN researchers have found a fluorescent protein in eels that potently binds bilirubin and might provide a simpler and more reliable diagnostic than existing ones. Convincing hospitals to invest in a new detection …

    Published on 6/27/2013
  • Finding drugs for the faint of heart

    Harvard researchers have developed an organ on a chip that recapitulates genetic, morphological and functional markers of failing myocardium. The system could help identify therapeutic candidates that slow or reverse …

    Published on 6/27/2013
  • Transferring flu protection

    Two independent studies provide proof of concept that gene transfer could be used to establish broad protection against influenza. Both groups are working to move their influenza A virus hemagglutinin-expressing vectors…

    Published on 6/20/2013
  • Figure 1: Model of receptor-mediated transcytosis of transferrin-containing nanoparticles

    Optimizing transferrin-mediated transcytosis Figure 1. Model of receptor-mediated transcytosis of transferrin-containing nanoparticles. Transferrin and its receptor are one of the ligand-receptor combinations that …

    Published on 5/30/2013
  • Optimizing transferrin-mediated transcytosis

    Caltech researchers have shown how modulating the transferrin content on gold nanoparticles can optimize their delivery into the brain via the transferrin receptor. The group now needs to determine whether its strategy …

    Published on 5/30/2013
  • Synthetic influenza seeds

    An international team led by Novartis and the J. Craig Venter Institute has improved the speed and accuracy of seed influenza virus production for large-scale vaccine manufacture. Adoption of the platform could shave …

    Published on 5/30/2013
  • Table 1: Stem cell types and methods for stem cell generation

    Tools: Finding a home for nuclear transfer Table 1. Stem cell types and methods for stem cell generation. There are three major classes of stem cells: embryonic stem cells (ESCs), induced pluripotent stem (iPS) cells…

    Published on 5/23/2013
  • Finding a home for nuclear transfer

    Oregon Health & Science University researchers have for the first time generated stable lines of human embryonic stem cells via somatic cell nuclear transfer. Whether the platform can carve a niche among existing stem …

    Published on 5/23/2013

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