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  • Parsing resistance pathways

    Barcoded cDNA screen can identify resistance pathways against cancer therapies

    A new strategy that homes in on major nodes of cancer pathways offers a faster and more informative way to find mutations that cause drug resistance than the standard needle-in-haystack approach.

    Published on 1/22/2015
  • Figure: Boosting ADCC with IgGA

    Boosting IgG with IgAtitle Tools & Techniques Boosting ADCC with IgGA [I] As described in Kelton, W. et al., replacing sections of the CH2 and CH3 domains in the IgG Fc region with sections from IgA yields IgGA, a …

    Published on 1/15/2015
  • Tools & Techniques: The right culture

    Mandating cell line validation addresses irreproducibility but poses challenges

    Stakeholders agree that mandating new methods to authenticate cell lines can improve reproducibility in research, but they don't agree on who should lead the charge.

    Published on 1/15/2015
  • Box: Journals take on reproducibility

    The right culture Tools & Techniques Journals take on reproducibility While any one journal cannot single-handedly mandate best practices to the entire research community, together they can promote consensus …

    Published on 1/15/2015
  • Boosting IgG with IgA

    UT Austin's IgGAs could induce more potent leukocyte-mediated killing than IgGs

    A UT Austin team has engineered chimeric mAbs that induce more potent leukocyte-mediated killing of targeted cells than conventional IgGs.

    Published on 1/15/2015
  • Pain in the dish

    In vitro methods of creating pain neurons could lead to new therapeutics

    Two new methods for creating pain fibers in vitro from fibroblasts could improve the odds for new pain therapeutics.

    Published on 1/8/2015
  • Figure 1: Genocea's ATLAS technology

    Tools: Genocea's mark on malaria Figure 1. Genocea's ATLAS technology. Full-length proteins of the pre-erythrocytic Plasmodium falciparum proteome are generated in Escherichia coli that expresses cytosolic Listeria …

    Published on 12/18/2014
  • Genocea's mark on malaria

    Genocea has identified an immunological imprint in patients with malaria and is using a $1.2 million grant from the Gates Foundation to turn the findings into a vaccine.

    Published on 12/18/2014
  • Roche's heart for diabetes

    Roche scientists have developed a cell-based model of diabetic cardiomyopathy, but they say it is only step one en route to a system that properly represents ventricles of a diseased heart.

    Published on 12/4/2014
  • Figure 1: Paper-based diagnostic tests

    Tools: Paperback diagnostics Figure 1. Paper-based diagnostic tests. [a] A synthetic RNA switch is designed to detect a specific oligonucleotide sequence called trigger mRNA, which acts as a marker for a particular …

    Published on 11/20/2014
  • HemoShear's human touch

    HemoShear's in vitro tumor model shows a new application for its tissue modeling technology and could open it to business from oncology companies.

    Published on 11/20/2014
  • Paperback diagnostics

    A paper-based diagnostic using RNA switches could provide an easily distributed, rapid test for infectious diseases in point-of-care settings.

    Published on 11/20/2014
  • Box 1: Defined and virus free

    Tools: Building blood vessels Box 1. Defined and virus free. Researchers at the Houston Methodist Research Institute and Stanford University have published data in Circulation describing a viral vector-free …

    Published on 11/13/2014
  • Building blood vessels

    Indiana University researchers have found a route to building blood vessels by developing a protocol to generate mass quantities of endothelium-forming cells.

    Published on 11/13/2014
  • SQZ Biotech's main squeeze

    Two awards totaling over $300,000 will fuel SQZ Biotech's scale-up of its microfluidics-based CellSqueeze platform that delivers bioactive materials directly into cells.

    Published on 11/13/2014
  • Figure 1: Process for creating a 3D neuronal model of Alzheimer's disease

    Tools: AD goes 3D Figure 1. Process for creating a 3D neuronal model of Alzheimer's disease. [a] Human neuronal progenitor cells are transfected with lentivirus encoding mutant forms of amyloid precursor protein (APP…

    Published on 11/6/2014
  • AD goes 3D

    A 3D neuronal culture model of Alzheimer's disease is much improved over earlier models, but researchers disagree on whether it is close enough to human disease for use in drug discovery.

    Published on 11/6/2014
  • Sex matters at the NIH

    The NIH is taking steps to make the inclusion of both sexes in preclinical studies a standard practice.

    Published on 10/30/2014
  • Figure 1: CRISPR's double-edged knife

    Tools: Programmable sensitivity Figure 1. CRISPR's double-edged knife. Treatment of antibiotic-resistant bacteria with a clustered, regularly interspaced short palindromic repeats (CRISPR)-Cas9 agent yields different…

    Published on 10/23/2014
  • Programmable sensitivity

    CRISPR-based antimicrobials can resensitize antibiotic-resistant bacteria by targeting specific resistance genes and could add new tools for combating resistance.

    Published on 10/23/2014
  • A CRISPR possibility for DMD

    Findings that CRISPR-based genome editing can improve symptoms in a mouse model of Duchenne muscular dystrophy could lead to a therapeutic use of the technology, whose impact has thus far been as a research tool.

    Published on 10/2/2014
  • Figure 1: Biospleen design

    Tools: Bad blood Figure 1 Biospleen design. The biospleen fluidic device incorporates a high-flow vascular arterial channel, which is perfused with septic whole blood. That channel is interconnected by open slits to …

    Published on 9/18/2014
  • Bad blood

    Whereas pharmacological approaches to treat sepsis have languished in the clinic, a microfluidic device developed by a Massachusetts team cleanses pathogens and endotoxins from blood and increases survival in rat models…

    Published on 9/18/2014
  • Box 1: Cyclotide synthesis

    Tools: Circling back to basics Box 1. Cyclotide synthesis. Although synthetic macrocycle chemistry has been inspired by the study of natural products such as cyclosporine, the biosynthetic pathways for many …

    Published on 8/21/2014
  • Circling back to basics

    Creating potent and orally bioavailable macrocycles is more challenging than developing small molecules, but a trio of studies could close the gap by proposing new design guidelines, identifying protein-protein …

    Published on 8/21/2014

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