Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Brain cancer

Growth factor independent 1 transcription repressor (GFI1); GFI1B

In vitro and mouse studies suggest inhibiting GFI1 or GFI1B could help treat some types of medulloblastomas. In whole-genome sequencing of human group 3 or 4 medulloblastoma samples, which are the predominant forms of pediatric medulloblastoma, somatic structural variants were identified that activated GFI1 or GFI1B. In immunocompromised mice, transplantation of neural stem cells expressing either GFI1 or GFI1B with c-Myc (MYC) induced aggressive and often metastatic cancers, whereas expression of GFI1, GFI1B or MYC alone failed to induce tumorigenesis. Next steps include testing the effects of GFI1 or GFI1B inhibition in medulloblastoma models.

SciBX 7(29); doi:10.1038/scibx.2014.854
Published online July 31, 2014

Patent and licensing status unavailable

Northcott, P.A. et al. Nature; published online June 22, 2014;
doi:10.1038/nature13379
Contact: Stefan M. Pfister, German Cancer Research Center, Heidelberg, Germany
e-mail:
s.pfister@dkfz-heidelberg.de

Contact: Peter Lichter, same affiliation as above
e-mail:
m.macleod@dkfz-heidelberg.de

Contact: Robert J. Wechsler-Reya, Sanford-Burnham Medical Research Institute, La Jolla, Calif.
e-mail:
rwreya@sanfordburnham.org

Contact: Jan O. Korbel, European Molecular Biology Laboratory, Heidelberg, Germany
e-mail:
korbel@embl.de