Indication

Target/marker/pathway

Summary

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Publication and contact information

Infectious disease

Bacterial infection

Unknown

Cell culture studies suggest an aromatic polyketide from Clostridium beijerinckii could be useful for treating bacterial infections. In a panel of bacteria, the peptide called clostrubin inhibited growth of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE) and several strains of mycobacteria with higher potency than that of ciprofloxacin. Next steps could include developing optimized clostrubin analogs.
Ciprofloxacin is a generic fluoroquinolone antibiotic.

SciBX 7(25); doi:10.1038/scibx.2014.739
Published online June 26, 2014

Patent and licensing status unavailable

Pidot, S. et al. Angew. Chem. Int. Ed.; published online May 14, 2014;
doi:10.1002/anie.201402632
Contact: Christian Hertweck, Hans Knoell Institute, Jena, Germany
e-mail:

christian.hertweck@hki-jena.de