Thursday, June 26, 2014
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Epidermal growth factor receptor (EGFR);
necrosis factor receptor superfamily member 9 (TNFRSF9;
Studies in mice and human
samples suggest sequential treatment with anti-EGFR and anti-CD137 antibodies
could help treat EGFR+ tumors. In EGFR+ mouse
xenograft and syngeneic tumor models, the anti-EGFR mAb Erbitux
increased the number of Cd137+ NK cells in
blood, spleen and tumors, and subsequent treatment with BMS-663513,
an anti-CD137 antibody, increased tumor regression and prolonged survival
compared with either antibody alone. In samples from patients with head and
neck cancer, Erbitux increased the number of CD137+ NK cells by 4%-15% compared with pretreatment
numbers. Next steps include designing a clinical trial of anti-EGFR plus
Lilly and Co., Bristol-Myers
Squibb Co. and Merck
KGaA market Erbitux to treat colorectal and head and neck
Inc. markets the anti-EGFR mAb Vectibix
to treat colorectal and other types of cancer.
BMS-663513 is in Phase I trials to treat solid tumors.
Inc.'s anti-CD137 antibody, PF-05082566,
is in Phase I trials to treat cancers including non-Hodgkin's lymphoma (NHL).
Published online June 26, 2014
Patent and licensing status
Kohrt, H.E. et al. J.
Clin. Invest.; published online May 16, 2014;
Contact: Holbrook E. Kohrt, Stanford University Medical
Center, Stanford, Calif.
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