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Gastrointestinal disease

Colitis

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In vitro and rat studies suggest synthetic disialyl hexasaccharides could help prevent necrotizing enterocolitis in infants. Human milk oligosaccharides including disialyllacto-N-tetraose (DSLNT) contribute to the gut health of breastfed infants but are difficult to synthesize. In a neonatal rat model of necrotizing enterocolitis, the synthetic disialyl hexasaccharides disialyllacto-N-neotetraose (DSLNnt) and a2-6-linked disialyllacto-N-tetraose (DSʹLNT) protected rats from necrotizing enterocolitis with potency comparable to that of human milk oligosaccharides. Next steps include testing the synthetic hexasaccharides in additional animal models.

SciBX 7(25); doi:10.1038/scibx.2014.737
Published online June 26, 2014

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Yu, H. et al. Angew. Chem. Int. Ed.; published online May 21, 2014;
doi:10.1002/anie.201403588
Contact: Xi Chen, University of California, Davis, Calif.
e-mail:

xiichen@ucdavis.edu