Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Diabetes

Glycerol-3-phosphate dehydrogenase 2 mitochondrial (GPD2)

Rodent and in vitro studies suggest inhibiting GPD2 can help treat type 2 diabetes. In rat mitochondrial lysates, metformin was shown to inhibit the redox shuttle enzyme GPD2. In rats and mice, an antisense oligonucleotide targeting Gpd2 or knockout of Gpd2 blocked metformin-mediated effects on glucose homeostasis, endogenous glucose production and cellular redox state. Next steps could include developing pharmacological GPD2 inhibitors.

SciBX 7(24); doi:10.1038/scibx.2014.710
Published online June 19, 2014

Patent and licensing status unavailable

Madiraju, A.K. et al. Nature;
published online May 21, 2014;
doi:10.1038/nature13270
Contact: Gerald I. Shulman, Yale School of Medicine, New Haven, Conn.
e-mail:
gerald.shulman@yale.edu