Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Autoimmune disease

Asthma

Serum/glucocorticoid regulated kinase 1 (SGK1)

Cell culture and mouse studies suggest inhibiting SGK1 could help treat asthma. In a mouse model of allergic asthma, T cell-specific knockout of Sgk1 led to an antigen-induced T helper type 1 (Th1) cell response and decreased levels of allergic markers, whereas wild-type mice developed a pathogenic Th2 cell response. Mice with the T cell-specific Sgk1 knockout were protected from allergen-induced inflammatory lung disease.
Next steps could include testing small molecule inhibitors of SGK1 in animal models of allergic asthma.

SciBX 7(17); doi:10.1038/scibx.2014.480
Published online May 1, 2014

Patent and licensing status unavailable

Heikamp, E.B. et al. Nat. Immunol.; published online April 6, 2014;
doi:10.1038/ni.2867
Contact: Jonathan D. Powell, The Johns Hopkins University School of Medicine, Baltimore, Md.
e-mail:

poweljo@jhmi.edu