Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Pain

MicroRNA let-7b
(MIRLET7B; LET-7B); toll-like receptor 7 (TLR7); transient receptor potential A1 (TrpA1)

Cell culture and mouse studies suggest inhibiting extracellular MIRLET7B could help treat pain. In mouse dorsal root ganglion neurons, the pain-inducing chemical formalin increased Mirlet7b secretion compared with vehicle. In these neurons, Mirlet7b was shown to bind to Tlr7 and result in subsequent activation of Trpa1, a cation channel associated with inflammatory pain. In mouse models of formalin-induced inflammatory pain, pretreatment with a Mirlet7b-inhibiting oligomer decreased pain-related behaviors compared with pretreatment using a scrambled control oligomer. Planned work includes identifying whether other miRNAs activate nociceptive neurons.

SciBX 7(16); doi:10.1038/scibx.2014.468
Published online April 24, 2014

Unpatented; unlicensed

Park, C.-K. et al. Neuron; published online April 2, 2014;
doi:10.1016/j.neuron.2014.02.011
Contact: Ru-Rong Ji, Duke University Medical Center, Durham, N.C.
e-mail:

ru-rong.ji@duke.edu