Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Obesity

Ubiquitin D (UBD; FAT10)

Mouse studies suggest inhibiting FAT10 could help treat obesity. In mice, knockout of Fat10 led to smaller adipocyte size and less weight gain than no alteration. In the knockout mice, energy expenditure during the day increased compared with that of wild-type controls. Next steps include developing therapeutic strategies to mimic the Fat10 knockout phenotype.

SciBX 7(16); doi:10.1038/scibx.2014.463
Published online April 24, 2014

Unpatented; available for partnering

Canaan, A. et al. Proc. Natl. Acad. Sci. USA; published online March 24, 2014;
doi:10.1073/pnas.1323426111
Contact: Allon Canaan, Yale School of Medicine, New Haven, Conn.
e-mail:

allon.canaan@yale.edu