This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

HIV/AIDS

HIV gp120

Mouse studies suggest combining antiretroviral therapy with an HIV gp120-targeting immunotoxin could help eliminate chronic HIV infection. In a mouse model of HIV with humanized bone marrow, liver and thymus, a combination of three antiretroviral therapies reduced but did not eliminate viral RNA, and addition of an anti-gp120 immunotoxin further decreased tissue levels of viral RNA by specifically eliminating virus-infected cells. Next steps could include testing the combination in primate models.

SciBX 7(6); doi:10.1038/scibx.2014.176
Published online Feb. 13, 2014

Patent and licensing status unavailable

Denton, P.W. et al. PLoS Pathog.; published online Jan. 9, 2014;
doi:10.1371/journal.ppat.1003872
Contact: J. Victor Garcia,
The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, N.C.
e-mail:
victor_garcia@med.unc.edu