This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Prostate cancer

G protein-coupled receptor kinase 3 (GRK3; ADRBK2)

Mouse and human sample studies suggest inhibiting ADRBK2 could help suppress prostate cancer growth and metastasis. In mice orthotopically transplanted with human prostate cancer cells, shRNA against ADRBK2 decreased primary tumor growth compared with control shRNA, whereas overexpression of ADRBK2 increased primary tumor growth and metastasis to the lung and lymph nodes compared with overexpression of green fluorescent protein. In human prostate tumor samples, elevated ADRBK2 expression correlated with malignancy, visceral metastasis and microvascular proliferation. Next steps include investigating ADRBK2's mechanism of action and identifying small molecule inhibitors of ADRBK2.

SciBX 7(6); doi:10.1038/scibx.2014.173
Published online Feb. 13, 2014

Patent status undisclosed; unavailable for licensing

Li, W. et al. Proc. Natl. Acad. Sci. USA; published online Jan. 13, 2014;
doi:10.1073/pnas.1320638111
Contact: Ed Harlow, Harvard Medical School, Boston, Mass.
e-mail:
eharlow@hms.harvard.edu
Contact: Wenliang Li, The University of Texas Health Science Center at Houston, Houston, Texas
e-mail:
wenliang.li@uth.tmc.edu