Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact
information

Cancer

Melanoma

G protein-coupled receptor 56 (GPR56)

Mouse studies suggest stimulating GPR56 activity could help reduce melanoma growth by preventing the deposition of excess extracellular matrix. In xenograft mice, knockdown of GPR56 in transplanted melanoma cells increased tumor growth compared with no alteration, but this effect was not seen in mice lacking transglutaminase 2 (Tgm2; Tg2). In a xenograft mouse model of melanoma, overexpression of GPR56 decreased extracellular deposition of Tg2 and fibronectin by driving GPR56 to bind to Tg2 and promote its endocytosis. Next steps include performing chemical screens for small molecules that can facilitate internalization of TG2 by GPR56.

SciBX 7(5); doi:10.1038/scibx.2014.141
Published online Feb. 6, 2014

Unpatented; licensing status not applicable

Yang, L. et al. Cancer Res.; published online Dec. 19, 2013;
doi:10.1158/0008-5472.CAN-13-1268
Contact: Lei Xu, University of Rochester, Rochester, N.Y.
e-mail:
lei_xu@urmc.rochester.edu