This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Musculoskeletal disease

Musculoskeletal disease

Cytoglobin (CYGB)

In vitro and mouse studies suggest increasing CYGB expression could help treat muscle injury. In mouse myoblasts, siRNA against Cygb increased reactive oxygen species levels and apoptotic cell death compared with siRNA control, whereas overexpression of Cygb decreased both. In mice, skeletal muscle-specific Cygb knockout impaired postinjury regeneration of muscle and differentiation and proliferation of myogenic progenitor cells. Next steps include additional studies to determine the mechanism of CYGB activity.

SciBX 7(4); doi:10.1038/scibx.2014.120
Published online Jan. 30, 2014

Patent application filing in progress; licensing status not applicable

Singh, S. et al. Proc. Natl. Acad. Sci. USA; published online Dec. 23, 2013;
doi:10.1073/pnas.1314962111
Contact: Pradeep P.A. Mammen, The University of Texas Southwestern Medical Center, Dallas, Texas
e-mail:

pradeep.mammen@utsouthwestern.edu
Contact: Beverly A. Rothermel, same affiliation as above
e-mail:

beverly.rothermel@utsouthwestern.edu