Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Breast cancer; pancreatic cancer

DNA

Mouse and cell culture studies suggest a mitochondria-targeted triphenylphosphonium derivative of the nitrogen mustard chlorambucil could help treat breast and pancreatic cancers. In a panel of breast and pancreatic cancer cell lines, the compound showed more potent anticancer activity than chlorambucil. In a mouse xenograft model of human pancreatic cancer, the compound decreased tumor growth compared with vehicle. Next steps could include developing optimized derivatives and evaluating them in additional animal models of breast and pancreatic cancers.

SciBX 6(46); doi:10.1038/scibx.2013.1313
Published online Dec. 5, 2013

Patent and licensing status unavailable

Millard, M. et al. J. Med. Chem.; published online Oct. 22, 2013;
doi:10.1021/jm4012438
Contact: Nouri Neamati, University of Michigan, Ann Arbor, Mich.
e-mail:

neamati@umich.edu
Contact: Bogdan Z. Olenyuk, University of Southern California, Los Angeles, Calif.
e-mail:

bogdan@usc.edu