This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

HBV

Activation-induced cytidine deaminase (AICDA; AID);
IL-1b; tumor necrosis factor-a (TNF-a)

In vitro studies suggest activating AID could help prevent HBV infection. In a cytokine screen in cultured hepatocytes, IL-1b and TNF-a decreased susceptibility to HBV infection and increased expression of AID compared with no treatment. In the hepatocytes, lentiviral vector-mediated expression of AID decreased HBV infection compared with an empty vector. Next steps include confirming the effect of IL-1b and TNF-a in an animal model and identifying therapeutics that activate the pathway.

SciBX 6(41); doi:10.1038/scibx.2013.1163
Published online Oct. 24, 2013

Findings unpatented; unavailable for licensing

Watashi, K. et al. J. Biol. Chem.; published online Sept. 11, 2013;
doi:10.1074/jbc.M113.501122
Contact: Hideki Aizaki, National Institute of Infectious Diseases, Tokyo, Japan
e-mail:
aizaki@nih.go.jp

Contact: Koichi Watashi, same affiliation as above
e-mail:
kwatashi@nih.go.jp