This week in therapeutics

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Target/marker/pathway

Summary

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Infectious disease

Infectious disease

Formyl peptide receptor 1 (FPR1)

Mouse studies suggest stimulating neutrophil-expressed FPR1 could help treat toxoplasmosis and other chronic gastrointestinal infections. In a mouse model of Toxoplasma gondii-related gastrointestinal infection, deletion of Fpr1 decreased neutrophil recruitment and bacterial encapsulation by neutrophils and increased mortality compared with no deletion. Next steps could include exploring the therapeutic potential of N-formyl peptide-mediated stimulation of FPR1 in models of chronic gastrointestinal infection such as inflammatory bowel disease (IBD).

SciBX 6(40); doi:10.1038/scibx.2013.1132
Published online Oct. 17, 2013

Patent and licensing status unavailable

Molloy, M.J. et al. Cell Host Microbe; published online Sept. 11, 2013;
doi:10.1016/j.chom.2013.08.003
Contact: Yasmine Belkaid, National Institutes of Health, Bethesda, Md.
e-mail:

ybelkaid@niaid.nih.gov