Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Nerve damage

Neurotrophic tyrosine kinase receptor 2 (NTRK2; TrkB)

Mouse studies suggest two TrkB agonists could be applied topically to treat nerve damage. In a mouse model of peripheral nerve injury, topical or systemic treatment with either of two previously described TrkB agonists-
7,8 dihydroxyflavone and deoxygedunin-both increased axon regeneration compared with controls that did not receive either compound. Next steps include testing the effects of the TrkB agonists on nerve function in mice and other animal models of nerve injury.

SciBX 6(39); doi:10.1038/scibx.2013.1102
Published online Oct. 10, 2013

Patent pending; available for licensing

English, A.W. et al. Proc. Natl. Acad. Sci. USA; published online Sept. 16, 2013;
doi:10.1073/pnas.1303646110
Contact: Arthur W. English, Emory University School of Medicine,
Atlanta, Ga.
e-mail:

medae@emory.edu