Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Hepatic disease

Liver disease

Proteasome activator subunit 3 (PSME3)

Mouse studies suggest inhibition of the proteasome activator PSME3 could help treat and prevent liver steatosis. In mice fed a high-fat diet, deletion of Psme3 prevented lipid accumulation and onset of liver steatosis. Next steps include analyzing the effects of Psme3 loss in other mouse models of obesity.

SciBX 6(39); doi:10.1038/scibx.2013.1098
Published online Oct. 10, 2013

Unpatented; licensing status not applicable

Dong, S. et al. Cell Metab.; published online Sept. 3, 2013;
doi:10.1016/j.cmet.2013.08.012
Contact: Chuangui Wang, Institute of Biomedical Sciences, Shanghai, China
e-mail:

cgwang@bio.ednu.edu.cn
Contact: Xiaotao Li, same affiliation as above
e-mail:

xiaotaol@bcm.edu