Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Stroke

Not applicable

Rodent studies suggest peritoneal dialysis could help decrease tissue damage after stroke. Ischemic brain injury causes the release of glutamate from damaged brain tissue to the blood, which causes tissue damage. In a rat model of brain ischemia, peritoneal dialysis 2.5 or 5 hours after infarction decreased plasma glutamate levels and infarct volume compared with no dialysis or dialysis that failed to remove glutamate. In the rats, the preserved brain tissue was viable and functional. Ongoing studies include a clinical safety trial of the approach.

SciBX 6(38); doi:10.1038/scibx.2013.1070
Published online Oct. 3, 2013

Findings patented; available for licensing

Godino, M.D. et al. J. Clin. Invest.; published online Sept. 3, 2013;
doi:10.1172/JCI67284
Contact: José Sánchez-Prieto, Complutense University of Madrid, Madrid, Spain
e-mail:
jsprieto@vet.ucm.es

Contact: Ignacio Lizasoain, same affiliation as above
e-mail:
ignacio.lizasoain@med.ucm.es