This week in therapeutics

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Inflammation

Asthma

Aspergillus fumigatus asperamide B

In vitro and mouse studies suggest inhibiting asperamide B could help treat asthma triggered by Aspergillus. In mice, A. fumigatus activated pulmonary invariant NK T (iNKT) cells and induced airway hyperresponsiveness, which was prevented by Cd1d knockout. In cocultures of bone marrow-derived cells and iNKT cells, asperamide B purified from A. fumigatus directly activated iNKT cells. Next steps include additional studies to understand how Aspergillus causes severe asthma.

SciBX 6(37); doi:10.1038/scibx.2013.1031
Published online Sept. 26, 2013

Provisional patent application filed; available for licensing

Albacker, L.A. et al. Nat. Med.; published online Sept. 1, 2013;
doi:10.1038/nm.3321
Contact: Dale T. Umetsu,
Harvard Medical School, Boston, Mass.
e-mail:
dale.umetsu@childrens.harvard.edu