This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Brain cancer

K(lysine) acetyltransferase 2B (KAT2B; PCAF)

Cell culture and mouse studies suggest inhibiting PCAF could help treat brain cancer by reducing sonic hedgehog homolog (SHH) signaling. A small interfering RNA screen of histone acetyltransferases found that knockdown of PCAF impeded SHH pathway activation. In glioblastoma and medulloblastoma cell lines, knockdown of PCAF decreased growth compared with no knockdown. In mice, intracranial injection of neural stem cells with PCAF knockdown led to lower tumor growth than injection of cells with no knockdown. Next steps include seeking collaborators to develop PCAF inhibitors.

SciBX 6(37); doi:10.1038/scibx.2013.1019
Published online Sept. 26, 2013

Unpatented; licensing status not applicable

Malatesta, M. et al. Cancer Res.; published online Aug. 13, 2013;
doi:10.1158/0008-5472.CAN-12-4660
Contact: Kristian Helin, University of Copenhagen, Copenhagen, Denmark
e-mail:
kristian.helin@bric.ku.dk