Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Pain

Hyaluronan and proteoglycan link protein 1 (HAPLN1; LPP)

In vitro studies suggest LPP could help treat intervertebral disc degeneration-associated chronic lower back pain. Treatment of the condition is aimed at regenerating the intervertebral disc matrix to reverse the degenerative disease. In 3D cultures of primary rabbit intervertebral disc cells, a human, 16-amino-acid, N-terminal LPP peptide upregulated a chondrocyte-specific transcription factor and levels of the extracellular matrix proteins aggrecan and collagen II. Next steps include testing the potential of LPP to induce expression of disc matrix components in animal models.

SciBX 6(36); doi:10.1038/scibx.2013.1003
Published online Sept. 19, 2013

Unpatented; licensing status not applicable

Wang, Z. et al. J. Biol. Chem.; published online Aug. 12, 2013;
doi:10.1074/jbc.M113.451948
Contact: Zili Wang, Atlanta VA Medical Center, Decatur, Ga.
e-mail:

zwang2@emory.edu