Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Pain

Formyl peptide receptor 1 (FRP1); 
a-hemolysin (aHL)

Mouse and cell culture studies suggest targeting bacterial FPR1 agonists and aHL could help treat infection-induced pain. In mouse models of pain, FRP1 agonists and aHL increased mechanical and heat hypersensitivity compared with saline. In these models, aHL-deficient bacteria caused less hypersensitivity than wild-type bacteria. In Fpr1-deficient mice, heat-killed bacteria had no effect on mechanical or heat sensitivity. Next steps include identifying additional bacterial mediators of pain (see Bacteria's painful truth, page 4).

SciBX 6(36); doi:10.1038/scibx.2013.1002
Published online Sept. 19, 2013

Unpatented; licensing status not applicable

Chiu, I.M. et al. Nature; published online Aug. 21, 2013;
doi:10.1038/nature12479
Contact: Clifford J. Woolf, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
e-mail:

clifford.woolf@childrens.harvard.edu