Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Autoimmune disease

Inflammatory bowel disease (IBD)

Vitamin D receptor (VDR)

Studies in mice and in patient samples suggest VDR activation could help treat IBD. In mouse models of IBD, overexpression of human VDR in intestinal epithelial cells decreased colitis severity compared with wild-type VDR expression. In Vdr knockout mice, expression of human VDR in intestinal epithelial cells decreased colitis severity and increased survival compared with no human VDR expression. In colonic biopsy samples from patients with IBD, VDR expression was lower than that in samples from normal subjects. Next steps could include testing VDR agonists in animal models of colitis.

SciBX 6(36); doi:10.1038/scibx.2013.985
Published online Sept. 19, 2013

Patent and licensing status unavailable

Liu, W. et al. J. Clin. Invest.; published online Aug. 15, 2013;
doi:10.1172/JCI65842
Contact: Yan Chun Li, The University of Chicago, Chicago, Ill.
e-mail:

cyan@medicine.bsd.uchicago.edu