This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Musculoskeletal disease

Muscle repair

Not applicable

Rabbit and rodent studies suggest decellularized skeletal muscle scaffolds could be used for muscle repair without inducing a rejection response. In rats, transplanted, decellularized skeletal muscle scaffolds derived from rabbits degenerated slower than transplanted, fresh rabbit skeletal muscle. In these rats, the xenogeneic, decellularized skeletal muscle scaffolds induced less of a transplant rejection response than fresh transplants and improved survival of xenogeneic cells. Next steps include evaluating similar pig-derived, decellularized matrices in nonhuman primates.

SciBX 6(35); doi:10.1038/scibx.2013.965
Published online Sept. 12, 2013

Unpatented; licensing status not applicable

Fishman, J.M. et al. Proc. Natl. Acad. Sci. USA; published online Aug. 12, 2013;
doi:10.1073/pnas.1213228110
Contact: Paolo De Coppi, UCL Institute of Child Health, London, U.K.
e-mail:
p.decoppi@ucl.ac.uk