This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Cell adhesion associated oncogene regulated (CDON; CDO); sonic hedgehog homolog (SHH)

Mouse studies suggest inhibition of CDON could help treat SHH+ tumors. In a mouse model of adenocarcinoma, homozygous deletion of Cdon increased tumor incidence and aggressiveness compared with wild-type Cdon expression. In a mouse xenograft model of lung cancer, small interfering RNA knockdown of Cdon and Shh increased tumor volume compared with knockdown of Shh alone. In a xenograft mouse model of lung cancer, an inhibitor of the SHH-CDON interaction decreased tumor volume compared with saline. Next steps include IND-enabling studies on the identified inhibitor.

SciBX 6(35); doi:10.1038/scibx.2013.955
Published online Sept. 12, 2013

Patent application filed by Netris Pharma; available for licensing

Delloye-Bourgeois, C. et al. PLoS Biol.; published online Aug. 6, 2013;
doi:10.1371/journal.pbio.1001623
Contact: Patrick Mehlen, University of Lyon, Lyon, France
e-mail:
patrick.mehlen@lyon.unicancer.fr