Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Spinal cord injury (SCI)

Matrix metalloproteinase 9 (MMP9)

Mouse studies suggest antagonizing MMP9 in combination with physical therapy could be useful for treating SCI. In a mouse model of SCI, Mmp9 knockout plus physical therapy improved gait and led to lower local inflammation and greater white matter survival than no knockout or no physical therapy. Researchers did not disclose next steps, which could include testing MMP9 inhibitors in rodent models of SCI.

SciBX 6(34); doi:10.1038/scibx.2013.934
Published online Sept. 5, 2013

Patent and licensing status undisclosed

Hansen, C.N. et al. J. Neurosci.; published online Aug. 7, 2013;
doi:10.1523/JNEUROSCI.1576-13.2013
Contact: D. Michele Basso, The Ohio State University, Columbus, Ohio
e-mail:
michele.basso@osumc.edu