Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Sarcoma

Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2); hypoxia-inducible factor 1a (HIF1A; HIF1a)

Studies in human samples and mice suggest inhibiting PLOD2 could help prevent metastasis in patients with sarcoma. In the tumor microenvironment, PLOD2 is upregulated by HIF1A. In mouse models of sarcoma, small hairpin RNA against Hif1a or Plod2 or pharmacological inhibition of Plod2 signaling all decreased pulmonary metastasis compared with scrambled shRNA or no inhibition. In human sarcoma samples, HIF1A and PLOD2 expression were greater in metastatic tumors than nonmetastatic tumors. Next steps could include testing PLOD2 inhibition in additional animal models of sarcoma.

SciBX 6(34); doi:10.1038/scibx.2013.927
Published online Sept. 5, 2013

Patent and licensing status unavailable

Eisinger-Mathason, T.S.K. et al. Cancer Discov.; published online
Aug. 1, 2013;
doi:10.1158/2159-8290.CD-13-0118
Contact: M. Celeste Simon, University of Pennsylvania, Philadelphia, Pa.
e-mail:
celeste2@mail.med.upenn.edu