This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Bacterial infection

Not applicable

Rat studies suggest decreasing mitochondrial reactive oxygen species could help prevent kidney damage in acute infectious pyelonephritis. In a rat model of acute pyelonephritis, a mitochondria-targeted plastoquinone antioxidant called SkQR1 decreased kidney pathology and increased survival compared with no treatment. In this model, SkQR1 pretreatment prevented an increase in leukocyte numbers and leukocyte-produced reactive oxygen species. Next steps include additional preclinical studies to evaluate the plastoquinone antioxidant in additional nephrological and urological pathologies.
Mitotech LLC has mitochondria-targeted antioxidants, including SkQR1, in preclinical development.

SciBX 6(33); doi:10.1038/scibx.2013.894
Published online Aug. 29, 2013

SkQR1 and related molecules covered by issued and filed patents; licensing details available from Mitotech
Contact: Maxim Skulachev, Mitotech LLC, Moscow, Russia
e-mail:

max@mitotech.ru

Plotnikov, E.Y. et al. Proc. Natl. Acad. Sci. USA; published online
July 29, 2013;
doi:10.1073/pnas.1307096110
Contact: Dmitry B. Zorov, Lomonosov Moscow State University,
Moscow, Russia
e-mail:

zorov@genebee.msu.su