This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Obesity

Melanocortin 2 receptor accessory protein 2 (MRAP2)

Studies in human samples and in mice suggest activating MRAP2 could help treat obesity. In mice, heterozygous or homozygous deletion of Mrap2 increased obesity and visceral adiposity compared with no deletion. In human samples, rare mutations in MRAP2 were found in nonsyndromic, severely obese individuals but not in controls. Next steps could include understanding the mechanism by which MRAP2 affects body weight.

SciBX 6(32); doi:10.1038/scibx.2013.864
Published online Aug. 22, 2013

Patent and licensing status unavailable

Asai, M. et al. Science; published online July 19, 2013;
doi:10.1126/science.1233000
Contact: Joseph A. Majzoub, Boston Children's Hospital, Boston, Mass.
e-mail:
joseph.majzoub@childrens.harvard.edu

Contact: I. Sadaf Farooqi, Addenbrooke's Hospital, Cambridge, U.K.
e-mail:
isf20@cam.ac.uk