Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Neurology

Adenosine A2A receptor (ADORA2A); ecto-5ʹ-nucleotidase (NT5E; NT; CD73)

Mouse studies suggest inhibiting CD73 could help to improve memory by regulating adenosine signaling in the brain through ADORA2A. In mice, Cd73-derived adenosine was required for the activation and function of Adora2a in the striatum. Cd73-knockout mice showed better performance in memory tasks compared with wild-type controls. Next steps could include identifying and evaluating CD73-specific inhibitors in mouse models.

SciBX 6(31); doi:10.1038/scibx.2013.832
Published online Aug. 15, 2013

Patent and licensing status unavailable

Augusto, E. et al. J. Neurosci.; published online July 10, 2013;
doi:10.1523/JNEUROSCI.5817-12.2013
Contact: Rodrigo A. Cunha, University of Coimbra, Coimbra, Portugal
e-mail:

cunharod@gmail.com
Contact: Jiang-Fan Chen, Boston University, Boston, Mass.
e-mail:

chenjf@bu.edu