This week in therapeutics

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Infectious disease

Malaria

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A chemically inactivated, whole-parasite vaccine could help treat malaria infection. Mice immunized with red blood cells containing a chemically inactivated rodent plasmodium parasite rapidly cleared a plasmodium infection, whereas mice immunized with plasmodium-infected control red blood cells did not. In vitro, Plasmodium falciparum was attenuated by a DNA-alkylating agent. Next steps include starting a clinical trial of a chemically attenuated, whole-cell malaria vaccine this year.

SciBX 6(29); doi:10.1038/scibx.2013.762
Published online Aug. 1, 2013

Patent applications filed; unavailable for licensing

Good, M.F. et al. J. Clin. Invest.; published online July 1, 2013;
doi:10.1172/JCI66634
Contact: Michael F. Good, Griffith University, Gold Coast, Queensland, Australia
e-mail:
michael.good@griffith.edu.au