Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Diabetic neuropathy

Unknown

Cell culture and mouse studies suggest guaifenesin could help treat diabetic neuropathy. In cultured neurons, the (R)-enantiomer of guaifenesin, but not the (S)-enantiomer, increased neurite outgrowth compared with saline control. In a mouse model for streptozotocin-induced diabetes, oral treatment with the (R)-enantiomer of guaifenesin partially prevented the slowing of motor neuron conduction velocity, indicating prevention of peripheral neuropathy. Next steps could include testing the compounds in diabetic patients. Guaifenesin is a generic OTC expectorant.

SciBX 6(28); doi:10.1038/scibx.2013.729
Published online July 25, 2013

Patent and licensing status unavailable

Hadimani, M.B. et al. J. Med. Chem.; published online June 13, 2013;
doi:10.1021/jm400401y
Contact: Lakshmi P. Kotra, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
e-mail:
lkotra@uhnres.utoronto.ca