Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Bacterial infection

Unknown

Cell culture studies suggest anthracimycin derivatives could help treat bacterial infections. In bacterial cell culture, anthracimycin inhibited the growth of Gram-positive bacteria, including Bacillus anthracis and methicillin-resistant Staphylococcus aureus (MRSA), but showed little or no activity against Gram-negative bacteria. In culture, a derivative of anthracimycin inhibited the growth of both Gram-positive and Gram-negative bacteria. Next steps include developing more drug-like derivatives of anthracimycin and testing them in mouse models for MRSA infection.

SciBX 6(28); doi:10.1038/scibx.2013.724
Published online July 25, 2013

Unpatented; licensing status not applicable

Jang, K.H. et al. Angew. Chem. Int. Ed.; published online June 17, 2013;
doi:10.1002/anie.201302749
Contact: William Fenical, University of California, San Diego, La Jolla, Calif.
e-mail:
wfenical@ucsd.edu