Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Dermatology

Wounds; hair loss

Septin 4 (SEPT4; ARTS)

In vitro and mouse studies suggest inhibiting SEPT4 could help treat wounds and promote hair follicle regeneration. In Sept4 knockout mice, skin tissue showed higher progenitor cell numbers, including hair follicle stem cells, than tissue from wild-type animals. Sept4 knockout mice showed faster wound healing and hair follicle regeneration than wild-type controls. Next steps include creating SEPT4 antagonists and determining whether SEPT4 inhibition increases cancer risk.

SciBX 6(28); doi:10.1038/scibx.2013.721
Published online July 25, 2013

Findings unpatented; mouse models available for licensing

Fuchs, Y. et al. Science; published online June 20, 2013;
doi:10.1126/science.1233029
Contact: Hermann Steller, The Rockefeller University, New York, N.Y.
e-mail:
steller@rockefeller.edu
Contact: Elaine Fuchs, same affiliation as above
e-mail:
fuchslb@rockefeller.edu