Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Melanoma

Peroxiredoxin 2 (PRDX2)

Mouse studies suggest compounds that mimic PRDX2 activity could help prevent melanoma metastasis. In mice, melanoma cells pretreated with Prx2-targeting small interfering RNA showed greater lung metastasis than cells pretreated with control siRNA. In the same model, mice treated with gliotoxin, a fungal metabolite with peroxiredoxin-like activity, had lower lung metastasis than mice given vehicle. Next steps include testing the compound's efficacy in a genetic mouse model more relevant to metastatic melanoma in humans.

SciBX 6(28); doi:10.1038/scibx.2013.719
Published online July 25, 2013

Patent application filed; available for licensing through the Ewha University-Industry Collaboration Foundation

Lee, D.J. et al. Cancer Res.; published online June 7, 2013;
doi:10.1158/0008-5472.CAN-12-4226
Contact: Sang Won Kang, Ewha Womans University, Seoul, South Korea
e-mail:
kangsw@ewha.ac.kr