Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Addiction

Neuropeptide S receptor 1 (NPSR1; NPSR)

Rat studies suggest the NPSR antagonist NCGC84 could help treat alcoholism. In rats, NCGC84 prevented alcohol-induced activation of Mapk in addiction centers of the brain. In a rat model for addiction, NCGC84 decreased alcohol self-administration and alcohol-seeking behavior compared with vehicle. Next steps include optimizing NCGC84 and additional studies in models for alcohol dependence.

SciBX 6(26); doi:10.1038/scibx.2013.661
Published online July 11, 2013

Patented; available for licensing

Thorsell, A. et al. J. Neurosci.; published online Jun 12, 2013;
doi:10.1523/JNEUROSCI.4742-12.2013
Contact: Markus Heilig, National Center for Advancing Translational Sciences, Bethesda, Md.
e-mail:
mheilig@mail.nih.gov

Contact: Wei Zheng, same affiliation as above
e-mail:
wzheng@mail.nih.gov