This week in therapeutics

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Target/marker/pathway

Summary

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Publication and contact information

Neurology

Depression

Not applicable

Mouse studies suggest increasing ATP release from astrocytes could help treat depression. In mouse models for depression, intracerebroventricular infusion of ATP decreased depressive behaviors more rapidly than the generic antidepressant imipramine. In normal mice, inhibition of ATP release from astrocytes induced depressive behaviors. In mouse models for depression, intracerebroventricular infusion of ATP decreased depressive behaviors compared with vehicle. Next steps could include screening for compounds that stimulate ATP release from astrocytes.

SciBX 6(21); doi:10.1038/scibx.2013.523
Published online May 30, 2013

Patent and licensing status unavailable

Cao, X. et al. Nat. Med.; published online May 5, 2013;
doi:10.1038/nm.3162
Contact: Tian-Ming Gao, Southern Medical University, Guangzhou, China
e-mail:

tgao@smu.edu.cn
Contact: Xin-Hong Zhu, same affiliation as above
e-mail:

zhuxh@smu.edu.cn