This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cardiovascular disease

Thrombosis

Peptidyl arginine deiminase type IV (PADI4; PAD4)

Mouse studies suggest PAD4 inhibition could help treat or prevent thrombosis. PAD4 is required for the formation of neutrophil extracellular traps, which are components of thrombi. In a mouse model for deep vein thrombosis, thrombi formed in less than 10% of Padi4-deficient animals, whereas thrombi formed in more than 90% of wild-type animals. Padi4 knockout did not affect normal bleeding and platelet function. Next steps include developing inhibitors of PAD4.

SciBX 6(21); doi:10.1038/scibx.2013.518
Published online May 30, 2013

Patent application filed; available for licensing

Martinod, K. et al. Proc. Natl. Acad. Sci. USA; published online May 6, 2013;
doi:10.1073/pnas.1301059110
Contact: Denisa D. Wagner, Harvard Medical School, Boston, Mass.
e-mail:

denisa.wagner@childrens.harvard.edu