Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Heat shock
protein 90
(Hsp90); lysine-specific demethylase 4B (KDM4B; JMJD2B)

Cell culture studies suggest KDM4B activity could be reduced by blocking Hsp90. High KDM4B activity has been associated with tumorigenesis. In cell culture, Hsp90 interacted with KDM4B, and proteasome-mediated degradation of KDM4B was higher after pharmacological inhibition of Hsp90 than after no inhibition. Next steps include assessing the effect of Hsp90 inhibition on the stability of other histone demethylases.

SciBX 6(20); doi:10.1038/scibx.2013.488
Published online May 23, 2013

Unpatented; licensing status not applicable

Ipenberg, I. et al. J. Biol. Chem.; published online April 15, 2013;
doi:10.1074/jbc.C113.462770
Contact:
Nabieh Ayoub, Technion-Israel Institute of Technology, Haifa, Israel
e-mail:
ayoubn@technion.ac.il