This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Leishmaniasis

Not applicable

In vitro and hamster studies suggest new classes of quinazolinone analogs could help treat leishmaniasis. Chemical synthesis and in vitro testing identified multiple lead compounds, including two quinazolinone-triazine hybrids and a quinazolinone peptide. Those molecules inhibited replication of Leishmania donovani with IC50 values in the low micromolar or high nanomolar range. In a hamster model for leishmaniasis, selected lead compounds inhibited L. donovani replication by over 50% without causing observable toxicity. Future studies could include optimizing the lead compounds.

SciBX 6(19); doi:10.1038/scibx.2013.470
Published online May 16, 2013

Patent and licensing status unavailable

Sharma, M. et al. J. Med. Chem.; published online April 23, 2013;
doi:10.1021/jm400053v
Contact: Prem M.S. Chauhan, CSIR-Central Drug Research Institute, Lucknow, India
e-mail:
prem_chauhan_2000@yahoo.com