Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Trypanosome

Isoleucyl tRNA synthetase (IARS)

A study in mice suggests inhibiting IARS could help treat human African trypanosomiasis. In mice infected with Trypanosoma brucei, IARS knockdown in the parasite or treatment with an IARS inhibitor led to rapid clearance of infection. Next steps include partnering with medicinal chemists to identify lead compounds.

SciBX 6(18); doi:10.1038/scibx.2013.441
Published online May 9, 2013

Unpatented; licensing status not applicable

Cestari, I. & Stuart, K. J. Biol. Chem.; published online April 2, 2013;
doi:10.1074/jbc.M112.447441
Contact: Kenneth Stuart, Seattle Biomedical Research Institute, Seattle, Wash.
e-mail:

ken.stuart@seattlebiomed.org